3 Visit-to-visit Blood Pressure Variability Varies by Age Groups

Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia

“… 52 Long‐term BPV and BRS reduction on aging were also related to poor cardiovascular outcomes and increased mortality. 51 On the other hand, Veerman and coworkers found that there was no effect of aging on BPV because BPV in resting conditions in the normotensive group did not significantly differ between the elderly group compared to the adolescent and adult groups; however, it was found that along with aging, there was a decrease in DBP variation when in standing position and decrease of pulse (R‐R) interval variability. 53 …”

“…There is an interrelation between microcirculation and macrocirculation alterations that affect blood flow resistance resulting in BPV due to an increase in central systolic blood pressure (CSBP) in aging (Figure 1); In aging of microcirculation, there is a decrease in the diameter of the blood vessels lumen due to an increase in the media‐to‐lumen ratio which disrupts the process of dilation of blood vessels, in the long term there is an increase in vascular resistance which increases BP and BPV, indirectly causing remodeling and rigidness of blood vessels and altering macrocirculation while ultimately increases pulse waves and CSBP with complications of end‐organ damage 44,47,48 . Research shows that aging on blood vessel rigidity affects systolic BPV more, while diastolic BPV through its pathophysiology is influenced by endothelial function and the autonomic nervous system; But aging itself affects both systolic BPV and diastolic BPV 49–51 …”

“… 44 , 47 , 48 Research shows that aging on blood vessel rigidity affects systolic BPV more, while diastolic BPV through its pathophysiology is influenced by endothelial function and the autonomic nervous system; But aging itself affects both systolic BPV and diastolic BPV. 49 , 50 , 51 …”

“…Adoor and coworkers in explorative research on the healthy group found that aging affects the imbalance of neural regulation on cardiovascular so that there is a significant difference in BPV with aging and also significantly reduces baroreflex sensitivity (BRS) 52 . Long‐term BPV and BRS reduction on aging were also related to poor cardiovascular outcomes and increased mortality 51 . On the other hand, Veerman and coworkers found that there was no effect of aging on BPV because BPV in resting conditions in the normotensive group did not significantly differ between the elderly group compared to the adolescent and adult groups; however, it was found that along with aging, there was a decrease in DBP variation when in standing position and decrease of pulse (R‐R) interval variability 53 …”

“…44,47,48 Research shows that aging on blood vessel rigidity affects systolic BPV more, while diastolic BPV through its pathophysiology is influenced by endothelial function and the autonomic nervous system; But aging itself affects both systolic BPV and diastolic BPV. [49][50][51] The effect of aging on BPV, both as a risk factor and as a consequence, still needs more confirmatory research because there are still studies with different results. Adoor and coworkers in explorative research on the healthy group found that aging affects the imbalance of neural regulation on cardiovascular so that there is a significant difference in BPV with aging and also significantly reduces baroreflex sensitivity (BRS).…”