3-T ultrahigh-field intraoperative MRI for low-grade glioma resection

Pamir, M. Necmettin; Özduman, Koray

doi:10.1586/era.09.134

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…Diffusion tensor imaging may be helpful to identify functional anatomical tracts that are as important as the functioning areas themselves; this technique allows for careful surgical planning to minimize risk of deficits and distinguish between tumor cells and peritumoral edema [7]. Intraoperative MRI and MRS may be used to evaluate the degree of tumor resection during the surgical procedure and more clearly identify residual tumor [35,36].…”

Section: Surgerymentioning

confidence: 99%

Low-Grade Gliomas

et al. 2014

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Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in young, otherwise healthy patients and generally have an indolent course with longerterm survival in comparison with high-grade gliomas. Treatment options include observation, surgery, radiation, chemotherapy, or a combined approach, and management is individualized based on tumor location, histology, molecular profile, and patient characteristics. Moreover, in this type of brain tumor with a relatively good prognosis and prolonged survival, the potential benefits of treatment must be carefully weighed against potential treatmentrelated risks.We review in this article current management strategies for LGG, including surgery, radiotherapy, and chemotherapy. In addition,the importance of profiling the genetic and molecular properties of LGGs in the development of targeted anticancer therapies is also reviewed. Finally, given the prevalence of these tumors in otherwise healthy young patients, the impact of treatment on neurocognitive function and quality of life is also evaluated. The Oncologist 2014;19:403-413Implications for Practice: This review summarizes the epidemiology, presentation, diagnosis, and treatment of low-grade gliomas. The article discusses recent advances in genetic characterization of these tumors, which has become particularly important in guiding tumor identification and classification, and may in some cases offer information about prognosis and/or expected response to treatment.The major studies regarding the use of radiation, chemotherapy, and surgical approaches in the treatment of these tumors are discussed.This information will aid medical oncologists in understanding the challenges inherent in diagnosing and treating patients with low-grade gliomas, and in recognizing the important factors to consider in devising treatment plans.

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Section: Surgerymentioning

confidence: 99%

Low-Grade Gliomas

et al. 2014

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“…Although low-field iMRI was first available in the United States in 1994 at Brigham and Women's Hospital in Boston, Massachusetts as a 0.5 Tesla (T) double donut scanner (23), experience with only a few 3T systems has been reported recently (9,17,(24)(25)(26)(27)(28). The main advantage of performing iMRI at higher field strength is generally superior image quality due to a higher signal-to-noise ratio (SNR).…”

mentioning

confidence: 99%

3 Tesla intraoperative MRI for brain tumor surgery

Ginat

Swearingen

Curry

et al. 2013

J. Magn. Reson. Imaging

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Implementation of intraoperative magnetic resonance imaging (iMRI) has been shown to optimize the extent of resection and safety of brain tumor surgery. In addition, iMRI can help account for the phenomenon of brain shift and can help to detect complications earlier than routine postoperative imaging, which can potentially improve patient outcome. The higher signal-to-noise ratio offered by 3 Tesla (T) iMRI compared with lower field strength systems is particularly advantageous. The purpose of this article is to review the imaging protocols, imaging findings, and technical considerations related to 3T iMRI. To maximize efficiency, iMRI sequences can be tailored to particular types of tumors and procedures, including nonenhancing brain tumor surgery, enhancing brain tumor surgery, transsphenoidal pituitary tumor surgery, and laser ablation. Unique imaging findings on iMRI include the presence of surgically induced enhancement, which can be a potential confounder for residual enhancing tumor, and hyperacute hemorrhage, which tends to have intermediate signal on T1-weighted sequences and high signal on T2-weighted sequences due to the presence of oxyhemoglobin. MR compatibility and radiofrequency shielding pose particularly stringent technical constraints at 3T and influence the design and usage of the surgical suite with iMRI.

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“…Through real-time guidance, it allows for localization of tumors and their margins, and facilitates continuous assessment of surgical progress. Studies of patients who underwent LGG resection in an intraoperative MR imaging suite report encouraging results in terms of achieving greater extent of resection, 13,32,102 which impacts outcome. However, using standard structural imaging paradigms, the decision to presume low-grade histology on the basis of a nonenhancing lesion is a common mistake.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

Low-grade gliomas in adults

Sanai

Chang

Berger

2011

JNS

128

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In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

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3-T ultrahigh-field intraoperative MRI for low-grade glioma resection

Cited by 14 publications

References 28 publications

Low-Grade Gliomas

Low-Grade Gliomas

3 Tesla intraoperative MRI for brain tumor surgery

Low-grade gliomas in adults

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