3‐[¹¹C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

Assessment of insulin sensitivity in vivo in control and diabetic mice with a radioactive tracer of glucose transport: [125I]‐6‐deoxy‐6‐iodo‐D‐glucose

“…This behaviour confirms the fact that this iodinated analogue does not accumulate in the cells but reaches an equilibrium between the intra-and extracellular compartments. On the other hand, in skeletal muscle, 6-DIG activity remained stable over time, whereas with 3-OMG, activity decreased in all organs [19,20]. These results might be explained by slower efflux kinetics of 6-DIG compared with its influx kinetics, perhaps indicative of a difference in plasma-interstitial fluid equilibrium.…”

“…The second tracer is 3-O-methyl-D-glucose (3-OMG), which is a glucose analogue entering the cell through glucose transporters (GLUTs). 3-OMG is not phosphorylated or further metabolized and therefore leaves the cell using the same transporter [19,20]. The cellular uptake of 3-OMG allows true transport rates to be measured.…”

PET radiopharmaceuticals for metabolic imaging in oncology

“…[57,58]. Kinetic efflux models for glucose, based on 3-O-[ 11 C]MG, were developed and applied in animal [59] and clinical [60] studies. In isolated heart preparations, evidence for the formation of a phosphorylated metabolite, suspected to be 3-O-MG-6-phosphate, was reported [61].…”

Synthesis of [18F]-6-deoxy-6-fluoro-D-glucose ([18F]6FDG), a potential tracer of glucose transport

“…3-O-Methyl-d-glucose (3-OMG) is a glucose analog that enters the cell by glucose transport but is not phosphorylated, thus allowing transport rates to be measured without the complications of subsequent metabolism of the tracer. [12][13][14] This tracer has been labeled with carbon-11 and used for in vivo studies of glucose transport in the brain and the heart. [15][16][17][18][19] Despite the favorable characteristics of 3-OMG, its usefulness is limited by the short half-life of carbon-11 (20 min), which probably explains the small number of studies with this tracer.…”