3. Principles of controlling reactions in flow chemistry

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

“…This set-up facilitates recycling experiments in consecutive batch reactors as the compartment containing the enzyme is easily removed from one batch reactor and added to the next batch. Finally, flow chemistry also has the potential to overcome these problems and increase the productivity of biotransformations [25][26][27] . The benefits of immobilised catalysts can be further exploited in continuous flow, in terms of the ease of separation and re-use of the catalyst 28 .…”