3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment

Li, Mingxue; Wu, Canrong; Yang, Yueying; Zheng, Mengzhu; Yu, Si-Lin; Wang, Jinhui; Chen, Lixia; Li, Hua

doi:10.1007/s13402-021-00599-9

Cited by 27 publications

(18 citation statements)

References 127 publications

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“…PHGDH is upregulated in multiple tumor types, inhibiting tumor-cell proliferation, suggesting utility as a therapeutic target for cancer ( Li et al., 2021 ). PHGDH is expressed in multiple tissues, including skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Wang

Ding

et al. 2022

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Wang

Ding

et al. 2022

Poultry Science

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“…Ma et al demonstrated that glucose restriction induces PHGDH phosphorylation by p38 at Ser371, and in clinical pancreatic cancer specimens, the phosphorylation levels of PHGDH-Ser371 and PHGDH-Ser55 correlated with p38 and AMPK activity, respectively [37] . PHGDH may be associated with tumorigenic EMT through its association with The MAPK signaling pathway interacting with PI3K/AKT/mTOR signaling pathway may jointly promote tumor development [38,39] , suggesting that PHGDH may act through different mechanisms [40] . Although the current study 10/19 revealed a potential interaction between PHGDH and AMPK signaling pathway, further studies are needed to investigate how PHGDH precisely regulates the development of endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

PHGDH as a Prognostic-Related Biomarker in Endometrial Carcinoma Correlating with Immune Infiltrates

Zhang

Kong

Chen

et al. 2022

Preprint

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Background: PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer.Methods: Clinicopathological data were obtained from the Cancer Genome Atlas (TCGA). First, the expression of PHGDH in pan-cancer and its expression and prognostic value in endometrial cancer were investigated. The effect of PHGDH expression on the prognosis of endometrial cancer was analyzed by Kaplan-Meier plotter and Cox regression. The relationship between PHGDH expression and clinical features of endometrial cancer was analyzed by logistic regression analysis. Receiver operating characteristic (ROC) curves and nomograms were established. Possible cellular mechanisms were explored using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the Gene Ontology (GO), and gene set enrichment analysis (GSEA). Finally, TIMER and CIBERSORT were used to analyze the relationship between PHGDH expression and immune infiltration. CellMinerTM was used to analyze the drug sensitivity of PHGDH.Results: The results showed that PHGDH expression was significantly higher in endometrial cancer tissues than in normal tissues at mRNA and protein levels. Kaplan-Meier survival curves showed that patients in the high expression group had shorter overall survival (OS) and disease-specific survival (DSS) than patients in the low PHGDH expression group. Multifactorial COX regression analysis further supported that high PHGDH expression was an independent risk factor associated with prognosis in patients with endometrial cancer. The results showed estrogen response, mTOR, K-RAS, and epithelial mesenchymal transition (EMT) were differentially elevated in the high-expression group of the PHGDH group. CIBERSORT analysis showed that PHGDH expression is related to the infiltration of multiple immune cells. When PHGDH is highly expressed, the number of CD8+T cells decreases.Conclusions: PHGDH plays a vital role in the development of endometrial cancer, which is related to tumor immune infiltration, and can be used as an independent diagnostic and prognostic marker for endometrial cancer.

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“…Ma et al demonstrated that glucose restriction induces PHGDH phosphorylation by p38 at Ser371, and in clinical pancreatic cancer specimens, the phosphorylation levels of PHGDH-Ser371 and PHGDH-Ser55 correlated with p38 and AMPK activity, respectively [38] . PHGDH may be associated with tumorigenic EMT through its association with The MAPK signaling pathway interacting with PI3K/AKT/mTOR signaling pathway may jointly promote tumor development [39,40] , suggesting that PHGDH may act through different mechanisms [41] . Although the current study revealed a potential interaction between PHGDH and AMPK signaling pathway, further studies are needed to investigate how PHGDH precisely regulates the development of endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of PHGDH for Predicting Prognosis and Immunotherapy Response in Patients with Endometrial Carcinoma

Zhang

Kong

Zhao

et al. 2022

Preprint

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Background: PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer. Methods: Clinicopathological data of endometrial cancer were downloaded from the Cancer Genome Atlas database (TCGA). First, the expression of PHGDH in pan-cancer was investigated, as well as the expression and prognostic value of PHGDH in endometrial cancer. The effect of PHGDH expression on the prognosis of endometrial cancer was analyzed by Kaplan-Meier plotter and Cox regression. The relationship between PHGDH expression and clinical characteristics of endometrial cancer was investigated by logistic regression. Receiver operating characteristic (ROC) curves and nomograms were developed. Possible cellular mechanisms were explored using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the Gene Ontology (GO), and gene set enrichment analysis (GSEA). Finally, TIMER and CIBERSORT were used to analyze the relationship between PHGDH expression and immune infiltration. CellMinerTM was used to analyze the drug sensitivity of PHGDH. Results: The results showed that PHGDH expression was significantly higher in endometrial cancer tissues than in normal tissues at mRNA and protein levels. Kaplan-Meier survival curves showed that patients in the high expression group had shorter overall survival (OS) and disease free survival (DFS) than patients in the low PHGDH expression group. Multifactorial COX regression analysis further supported that high PHGDH expression was an independent risk factor associated with prognosis in patients with endometrial cancer. The results showed estrogen response, mTOR, K-RAS, and epithelial mesenchymal transition (EMT) were differentially elevated in the high-expression group of the PHGDH group. CIBERSORT analysis showed that PHGDH expression is related to the infiltration of multiple immune cells. When PHGDH is highly expressed, the number of CD8+T cells decreases. Conclusions: PHGDH plays a vital role in the development of endometrial cancer, which is related to tumor immune infiltration, and can be used as an independent diagnostic and prognostic marker for endometrial cancer.

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3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment

Cited by 27 publications

References 127 publications

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

PHGDH as a Prognostic-Related Biomarker in Endometrial Carcinoma Correlating with Immune Infiltrates

Comprehensive Analysis of PHGDH for Predicting Prognosis and Immunotherapy Response in Patients with Endometrial Carcinoma

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