3-Phenylpyrazolo(4,3-c)pyridine and derivatives: structure determination

Expedient Synthesis of 3-Alkoxymethyl- and 3-Aminomethyl-Pyrazolo[3,4-b]pyridines

“…Compounds in this class have demonstrated some biological activity . Fewer examples of this ring system appear in the literature, although some methods have been developed to access them. , Following the strategy reported herein, lithiation of 4-chloropyridine 26 and addition to Weinreb amide 6f gave 27 with good regioselectivity but only moderate yield (37% yield). Cyclization under the standard conditions then provided the desired pyrazolo[4,3- c ]pyridine 28 .…”