3-O-Methyldopa, a New Precursor of Dopamine

Bartholini, G.; Kuruma, Isami; Pletscher, A.

doi:10.1038/230533a0

Cited by 56 publications

(14 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…spectra of 6, 15 and 17 exhibited a stronger negative Cotton effect at N 280 nm than the corresponding cis-isomers 4, 14 and 16. It is noteworthy that the 3-0-methyl ether 10, due to the lowcr electron density at the point of ring closure [S], required rather drastic conditions to effect cyclization. It is therefore understandable that 10, a major metabolite of L-dopa in man [6], accumulates in mammalian tissue. 's (uncorrected) were taken in open capillary tubes with a Thomas-Hoover melting apparatus.…”

Section: )mentioning

confidence: 99%

‘Alkaloids’ in Mammalian Tissues. I. Condensation of L‐Dopa and its two mono‐O‐methyl ethers with formaldehyde and acetaldehyde

Brossi

Focella

Teitel

1972

Helvetica Chimica Acta

View full text Add to dashboard Cite

Zusammenfassung. I n der Annahme, dass gewisse Aminosauren im Gewebe von Saugetieren Vorlaufer fur salkaloidische >) Tetrahydro-isochinoline sein konnten, wurden L-Dopa und dessen zwei Monomethylather mit Formaldehyd und Acetaldehyd kondensiert. Die absolute Stereochemie der erhaltenen 1-Methyl-substituierten Tetrahydro-isochinoline wurde durch Rontgen-Analyse einer Schlusselverbindung sichergestellt.

show abstract

Section: )mentioning

confidence: 99%

‘Alkaloids’ in Mammalian Tissues. I. Condensation of L‐Dopa and its two mono‐O‐methyl ethers with formaldehyde and acetaldehyde

Brossi

Focella

Teitel

1972

Helvetica Chimica Acta

View full text Add to dashboard Cite

show abstract

“…A similar trend was observed in the quantitative determination of HVA, while the excretion profile of VMA was not markedly changed by MK-486 treatment. The increase in the 0-methylated acid metabolites after prolonged pretreatment with MK-486 might suggest that the metabolic conversion of DOPA to its major 0-methylated acid metabolite preceded by transamination of the formed 3-0-MD to the corresponding lactic acid, through pyruvic acid, to form HVA as has been recently suggested by Bartholini, Kuruma, and Pletscher (15). However, one cannot exclude the possibility that prolonged pretreatment with the inhibitor might induce enzymes involved in the oxidative deamination of L-DOPA-methylated metabolite (s).…”

Section: Resultsmentioning

confidence: 89%

Peripheral Aromatic L-Amino Acids Decarboxylase Inhibitor in Parkinsonism. I. EFFECT ON O-METHYLATED METABOLITES OF L-DOPA-2-14C

Messiha¹,

Hsu²,

Bianchine³

1972

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The effects of MK-486, an inhibitor of peripheral aromatic L-amino acids decarboxylase, on the urinary metabolites derived from orally administered L-Dopa-2-14C were studied in three Parkinsonian patients. Treatment with MK-486 before L-Dopa-2-14C markedly reduced radioactivity found in catecholamines fraction by 70-80% during 48 hr, but increased 3-0-methyldopa fraction by threefold, as compared with a nonpretreated base line value. Pretreatment with MK-486 for a period of 1 wk resulted in less inhibition of 0-methylated amine and acid metabolite fractions than that measured after a single dose of the inhibitor.

show abstract

“…Enhancement of ST by pretreatment with 3-OMD might be explained as a DA effect in view of the suggestion that 3-OMD can serve as a precursor for DA (2)(3)(4).…”

Section: Discussionmentioning

confidence: 99%

Ethanol Narcosis in Mice: Effects of <i>L</i>-dopa, its Metabolites and Other Experimental Variables

Messiha¹,

Morgan²,

Geller³

1975

Pharmacology

View full text Add to dashboard Cite

Ethanol-induced narcosis was studied in mice as a function of pretreatment with L-dopa and its metabolites administered alone or in conjunction with Ro-4-4602, an inhibitor of aromatic- L-amino acid decarboxylase. These studies suggest that L-dopa prolongation of ETOH narcosis in mice may be due to formation of one or more toxic metabolites rather than to a direct involvement of dopamine. Ethanol narcosis also was studied in mice as a function of age of animals, concentration of ETOH, ambient temperature and saline pretreatment. Since manipulation of these variables produced alterations in ETOH narcosis, the need for their rigid control is indicated.

show abstract

3-O-Methyldopa, a New Precursor of Dopamine

Cited by 56 publications

References 4 publications

‘Alkaloids’ in Mammalian Tissues. I. Condensation of L‐Dopa and its two mono‐O‐methyl ethers with formaldehyde and acetaldehyde

‘Alkaloids’ in Mammalian Tissues. I. Condensation of L‐Dopa and its two mono‐O‐methyl ethers with formaldehyde and acetaldehyde

Peripheral Aromatic L-Amino Acids Decarboxylase Inhibitor in Parkinsonism. I. EFFECT ON O-METHYLATED METABOLITES OF L-DOPA-2-14C

Ethanol Narcosis in Mice: Effects of <i>L</i>-dopa, its Metabolites and Other Experimental Variables

Contact Info

Product

Resources

About