3-nitrotyrosine shortens axons of a non-dopaminergic neuron by inhibiting mitochondrial motility
Masahiro Hirai,
Kohei Suzuki,
Yusuke Kassai
et al.
Abstract:3-nitrotyrosine (3-NT), a byproduct of oxidative/nitrosative stress, is implicated in age-related neurodegenerative disorders. Existing literature indicates that free 3-NT becomes integrated into the carboxy-terminal domain of α-tubulin through the tyrosination/detyrosination cycle. Independently of this integration, 3-NT has been linked to the cell death of dopaminergic neurons. Given the critical role of tyrosination/detyrosination in governing axonal morphology and function, the substitution of tyrosine wit… Show more
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