3-N-substituted-amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazolines have enhanced activity against arachidonate 5-lipoxygenase and cyclooxygenase

Cyclo Addition of Nitrile Imines and Diels-Alder Reaction of Anthracene to Isoxazolyl Maleimides

“…These synthons (2) are often generated in situ from hydrazonyl chlorides and trapped with dipolarophiles to give the corresponding Δ 2 -pyrazolines (3). A 2 -pyrazolines are of interest due to their biological activity (4,5) and physical applications (6,7). Maleimide compounds are an important class of substrates for biological and chemical applications (8).…”

Novel Synthesis of 1,3,5-Trisubstituted 2-Pyrazolines Promoted by Chlorotrimethylsilane

“…[1][2][3] Often the type and degree of substitution about the pyrazoline ring can have a profound effect on the biological activity of a given substrate. The biological activity of substituted pyrazolines and their derivatives has been found to possess anti-WNV (West Nile Virus), 4 anti-inflammatory, [5][6] antimicrobial, 7 anti-arrhythmic, antipyretic, tranquilising, muscle relaxant, psycho analeptic agents, [8][9][10] and human leukocyte elastase inhibitors. 11 In addition to the synthetic applications, variously substituted pyrazolines and their derivatives have been employed in the study of heterocyclic chemistry.…”

Synthesis of some pyrazolo[1,5-c][1,3]benzoxazines and a new 5H-pyrazolo[1,5-c][1,3,2]benzoxazaphosphorine ring system

“…In addition, certain 2-pyrazolines have been discovered to significantly inhibit both pathways of arachidonate metabolism [9,10], a feature that is of importance for novel cyclooxygenase inhibitors (COX-2) [11]. Besides being effective antiinflammatory drugs [12], COX-2 inhibitors can be used to treat various cancers [13], and also for prevention of neurodegenerative disorders such as Alzheimer's disease [14].…”