3‐<i>O</i>‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress

Katsuyama, Yushi; Taira, Norihisa; Tsuboi, Tatsuya; Yoshioka, Masato; Okano, Yasuaki; Hashimoto, Masaki

doi:10.1111/exd.13820

Cited by 4 publications

(5 citation statements)

References 18 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, PPAR‐α and PPAR‐γ, negative regulators of NF‐κB, are reported to be decreased in the inflamed lesions of psoriasis and AD 12,20 . On the contrary, DDH‐1 has been shown to exert an anti‐inflammatory effect by increasing the expression levels of PPAR‐α and PPAR‐γ 9–12 . Thus, we first confirmed the mRNA expression levels of PPAR‐α and PPAR‐γ in the skin lesions of AD‐like mice.…”

Section: Resultssupporting

confidence: 67%

“…Accordingly, DDH-1, but not ascorbic acid, has been shown to promote the expression levels of peroxisome proliferator activated receptor (PPAR)α and PPARγ, nuclear factor-kappa B (NF-κB) negative regulators, in cultured keratinocytes, leading to reduced expression levels of TNFα, IL-1β and IL-6. [9][10][11][12] In addition, we have also found that DDH-1 shows an anti-inflammatory effect on a psoriasis mouse model induced by topical imiquimod treatment. 12 Thus, DDH-1 may also be useful to prevent and treat other inflammatory skin diseases including AD.…”

mentioning

confidence: 65%

“…Of note, DDH‐1 has recently been reported to have an anti‐inflammatory effect through the suppression of pro‐inflammatory cytokine expression levels in vitro and in vivo, while ascorbic acid does not have this effect. Accordingly, DDH‐1, but not ascorbic acid, has been shown to promote the expression levels of peroxisome proliferator activated receptor (PPAR)‐α and PPAR‐γ, nuclear factor‐kappa B (NF‐κB) negative regulators, in cultured keratinocytes, leading to reduced expression levels of TNF‐α, IL‐1β and IL‐6 9–12 . In addition, we have also found that DDH‐1 shows an anti‐inflammatory effect on a psoriasis mouse model induced by topical imiquimod treatment 12 .…”

Section: Introductionmentioning

confidence: 83%

See 2 more Smart Citations

Anti‐allergic effect of ascorbic acid derivative DDH‐1 in a mouse model of atopic dermatitis

Kitahata

Matsuo

Sato

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

Atopic dermatitis (AD) is the most common inflammatory skin disease, which is characterized by excessive Th2 immune responses. In AD patients, the expression of the chemokines CCL17 and CCL22 is increased in skin lesions, leading to the infiltration of Th2 cells. In addition, typical pro‐inflammatory cytokines, including TNF‐α, IL‐1β and IL‐6, have also been shown to be associated with the pathogenesis of AD. Recently, DDH‐1, an ascorbic acid derivative, has been synthesized and demonstrated to have a more stabilized structure and better skin penetrability. Furthermore, DDH‐1 has been shown to suppress pro‐inflammatory cytokine expression in vitro and in vivo. Therefore, using an AD mouse model, we evaluated the effect of DDH‐1 to reduce allergic skin inflammation. We found that cutaneous administration of DDH‐1 significantly reduced the expression levels of TNF‐α, IL‐1β and IL‐6 in the skin lesions of AD‐like mice. Additionally, DDH‐1 administration also significantly reduced the expression levels of CCL17 and CCL22, resulting in decreased skin infiltration of Th2 cells. Consequently, DDH‐1 reduced ear and epidermal thickness, the serum IgE levels and the number of infiltrating inflammatory cells and mast cells into the AD‐like skin lesions. Combination treatment with DDH‐1 and corticosteroid more efficiently improved the skin lesions compared with corticosteroid alone. Collectively, our results suggest that DDH‐1 has an anti‐allergic effect in an AD mouse model by reducing not only the pro‐inflammatory cytokine expression but also the Th2‐associated chemokine expression. Thus, DDH‐1 may be beneficial for AD treatment and prevention as a monotherapy or in combination with corticosteroids.

show abstract

Section: Resultssupporting

confidence: 67%

mentioning

confidence: 65%

Section: Introductionmentioning

confidence: 83%

See 1 more Smart Citation

Anti‐allergic effect of ascorbic acid derivative DDH‐1 in a mouse model of atopic dermatitis

Kitahata

Matsuo

Sato

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Recent examples of using skin explants include studies on penetration and metabolism of vitamin A derivatives 41 and the effect of cigarette smoke exposure on skin barrier permeability. 42 Where 3D skin equivalents and skin explants really shine is in their ability to model aspects of human skin disorders, including dry skin, 58 radiodermatitis 59 or hidradenitis suppurativa 60 Using an inhibitor to GSK3B with and without sunitinib, the authors showed that MAPK signalling and skin barrier gene expression changes can both be rescued, suggesting that GSK3B inhibitors may be a clinically relevant treatment to HFSR.…”

Section: Where Org Anot Ypi C S Kin Culture S " S Hine"mentioning

confidence: 99%

“…Where 3D skin equivalents and skin explants really shine is in their ability to model aspects of human skin disorders, including dry skin, 58 radiodermatitis 59 or hidradenitis suppurativa 60 to name but a few. In this issue of Experimental Dermatology , Yoshida et al .…”

Section: Where Organotypic Skin Cultures “Shine”mentioning

confidence: 99%

Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models

Atwood

Plikus

2021

Experimental Dermatology

View full text Add to dashboard Cite

The field of experimental dermatology research has dramatically benefited from the insights yielded by in vivo studies on animal models. Indeed, much of our understanding of the mechanisms that regulate embryonic skin development, adult skin homeostasis and physiological skin responses to stress, such as wound healing, has been educated by studies conducted in animal models, including mutant mice. These works become commonly published on the pages of Experimental Dermatology and, in fact, represent one of the core interests of the journal. Highlighting in vivo mouse model studies are recent works on hair follicle development and growth 1-5 and wound healing. 6-8 Further, studies in animal models often help to elucidate aspects of disease pathogenesis, and mouse models are used to investigate mechanisms of human skin conditions such as atopic dermatitis, 9-13 contact dermatitis, 14-16 psoriasis, 17,18 rosacea 19 and squamous cell carcinoma 20 to name a few. On the other hand, not all human skin diseases or aspects of human skin physiology can be reliably modelled in rodents. This is not surprising, considering that humans and rodents are separated by an estimated 96 million years of evolution. 21 Addressing this fact, many studies are being conducted on patient-derived primary skin cells, including human keratinocytes, 22-25 melanocytes, 26-30 fibroblasts 31-34 and cell co-cultures. 35-37 However, typical in vitro culture conditions fail to replicate and, in fact, do not come close to imitating the biomechanical and biochemical complexity of the microenvironment in which cells exist and to which they respond to in native tissues. Further, ingredients in commonly used cell culture media and the two-dimensional constraints of growth on plastic result in cells being exposed to a lot of artificial cues, to which they adapt but also prominently alter their gene expression profile and functional activities in the process. Therefore, behaviours displayed by skin cells in twodimensional cultures need to be comprehensively validated under more native-like conditions in order to be deemed biologically and physiologically relevant. Helping to bridge the gap, threedimensional (3D) organotypic cultures and organ culture techniques have long been a highly instructive tool for investigating complex, tissue-level behaviours by skin cells.

show abstract

Human skin responses to environmental pollutants: A review of current scientific models

Fitoussi

Faure²,

Beauchef

et al. 2022

Environmental Pollution

View full text Add to dashboard Cite

3‐O‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress

Cited by 4 publications

References 18 publications

Anti‐allergic effect of ascorbic acid derivative DDH‐1 in a mouse model of atopic dermatitis

Anti‐allergic effect of ascorbic acid derivative DDH‐1 in a mouse model of atopic dermatitis

Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models

Human skin responses to environmental pollutants: A review of current scientific models

Contact Info

Product

Resources

About