3-Hz brain stimulation interferes with various aspects of the kindling effect

Gaito, John

doi:10.3758/bf03335015

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…The brain coordinates for electrode implantation were the same as in many experiments in our laboratory: .5 mm posterior to bregma, 4.5 mm from midline, 8.5 mm from skull (bregma as reference point; Gaito, 1979). With these coordinates, the electrode tips were aimed at the central part of the amygdala, approximately in the intercalated nucleus.…”

Section: Methodsmentioning

confidence: 99%

“…In a series of experiments, we found that 1-or 3-Hz sine-wave stimulation at moderate intensities before and/or after a 6O-Hzstimulation trial suppressed the tendency of the 60-Hz current to produce kindling behavior (Gaito, 1979, 1980a, 1980bGaito, Nobrega, & Gaito, 1980). The experiments with 3-Hz stimulation were conducted at an intertrial interval of 1 h between the imposition of the 3-and 6O-Hz stimulation trials.…”

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Lack of interhemispheric transfer of the 1-Hz suppression effect in rats

Gaito

1984

Psychobiology

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Three experiments were conducted to evaluate the effect of 1-Hzbrain stimulation of the amygdala on kindling behavior induced by 60-Hz sine-wave stimulation in the contralateral amygdala. In Experiment 1, the effective threshold intensity (ETI) to elicit a kindled response with 60-Hz stimulation was determined on four separate occasions with 15 trials between determinations (three per day) for each of three groups. Experimental rats in Group 1 were stimulated with 1-Hz sine waves in one amygdala, then with 60-Hz current in the opposite amygdala, followed by 1-Hz stimulation of the first site (1-60-1, OA), with 1-h interstimulation intervals. Group 2 was treated with the 1-60-1 pattern, but with all stimulation in the same amygdala (1-60-1, SA). Group 3 received only the 60-Hz stimulation trials (X-60-X), on the second trial. Group 2 showed the typical suppression result, a gradual increase in threshold over the four ETI determinations. However, Group l's responses were similar to those of Group 3: ETI values decreased gradually over the determinations. Later, when Group 1 received a set of trials in which 1-and 60-Hz current stimulation was to the same site, suppression responses occurred. Two further experiments were conducted with similar results. These results suggest that the suppression effect generated by 1-Hz stimulation appears to involve a local process, an intrahemispheric effect.

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Section: Methodsmentioning

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Lack of interhemispheric transfer of the 1-Hz suppression effect in rats

Gaito

1984

Psychobiology

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Gradient of Interference by Various Frequencies on 60 Hz Kindling Behavior

Gaito¹

1980

Can. j. neurol. sci.

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The Effect of Several Intertrial Intervals on the 1 Hz Interference Effect

Gaito¹,

Gaito²

1981

Can. j. neurol. sci.

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SUMMARYExperiments were conducted to evaluate the effect of two intertrial intervals of 1-Hz brain stimulation on kindling behavior induced by 60-Hz sine wave stimulation. In two experiments, the effective threshold intensity (ETI) to elicit a convulsion was determined on four separate occasions with 5 days of daily trials between determinations. On each day experimental rats were stimulated with 1-Hz current on the first and third trials for 120 seconds duration and with 60-Hz current for 30 seconds on the second trial (1-60-1 group). A second group was stimulated with 60-Hz current on each trial (60-60-60 group). A third group received no stimulation on Trials 1 and 3 and 60-Hz current on Trial 2 (X-60-X group). In Experiment I, the intertrial interval was 3 hours; a 24 hour interval was used in Experiment 2. The results were similar in both experiments. For the 1-60-1 group, there was a steady increase in the intensity required to elicit a convulsion with 60-Hz current from ETI to ETI. However, the 24 hour interval produced a lesser effect than did the 3 hour interval (or the 1 hour interval used in previous experiments). Rats in the other groups maintained relatively stable values from ETI to ETI, with a slight decline occurring. Suppression of convulsive behaviour on daily trials was present with the 1-60-1 groups, and nonexistent with the other groups.

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3-Hz brain stimulation interferes with various aspects of the kindling effect

Cited by 12 publications

References 9 publications

Lack of interhemispheric transfer of the 1-Hz suppression effect in rats

Lack of interhemispheric transfer of the 1-Hz suppression effect in rats

Gradient of Interference by Various Frequencies on 60 Hz Kindling Behavior

The Effect of Several Intertrial Intervals on the 1 Hz Interference Effect

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