3-hydroxy-3-methylglutaric acid (HMGA) reduces dietary cholesterol induction of saturated bile in hamster

Padova, C. Di; Bosisio, E.; Cighetti, Giuliana; Rovagnati, P; Mazzocchi, M; Colombo, Carla; Tritapepe, R

doi:10.1016/0024-3205(82)90471-4

Cited by 12 publications

(5 citation statements)

References 22 publications

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“…HMG elicits significant hypoglycemic responses and is used as an HMG CoA lyase competitive inhibitor to treat Diabetes mellitus and hypocholesterolemic atherosclerosis. [40][41][42][43][44] Furthermore, the properties of flax seed are presumably also enhanced by the presence of alkali releasable p-coumaric acid (8b) and ferulic acid (10b) glucosides, both of which exhibit antioxidant and some breast and colon cancer chemopreventive properties. 45,46 Finally, in attempting to explain the observation made on metabolic buildup (of radiochemical intermediates) during flax seed development, it needs to be recognized that the tissue is also very heterogeneous.…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, the joint bioavailability of SDG ( 1 ) and HMG ( 21 ) in flax seed may explain why in some studies seeds are more efficacious than SDG ( 1 ) alone. HMG elicits significant hypoglycemic responses and is used as an HMG CoA lyase competitive inhibitor to treat Diabetes mellitus and hypocholesterolemic atherosclerosis. − Furthermore, the properties of flax seed are presumably also enhanced by the presence of alkali releasable p -coumaric acid ( 8b ) and ferulic acid ( 10b ) glucosides, both of which exhibit antioxidant and some breast and colon cancer chemopreventive properties. , …”

Section: Resultsmentioning

confidence: 99%

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Biosynthetic Pathway to the Cancer Chemopreventive Secoisolariciresinol Diglucoside−Hydroxymethyl Glutaryl Ester-Linked Lignan Oligomers in Flax (Linum usitatissimum) Seed

et al. 2001

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Application of stable and radioisotope precursor/tracer experiments resulted in the identification of various phenylpropanoid, monolignol, and lignan metabolites involved in the biosynthesis of the cancer chemopreventive secoisolariciresinol diglucoside (SDG; 1)-containing ester-linked "polymer(s)" in flax (Linum usitatissimum) seed. Individual analysis of size-segregated flax seed capsules at five early stages of their development provided a metabolic profile of intermediates leading to "biopolymer" biosynthesis. The use of (1)H and (13)C NMR and HRMS analyses resulted in the identification of 6a-HMG (hydroxymethyl glutaryl) SDG (17) and 6a,6a'-di-HMG SDG (18) as the two major components of the ester-linked "biopolymer(s)". Based on metabolic tracer analyses and relative radioisotopic incorporations throughout each of these five stages of seed development, a biochemical pathway is proposed from phenylalanine to SDG (1), with subsequent mono- and di-substitutions of SDG (1) with HMG CoA. These metabolites then serve as precursors for formation of the SDG-HMG ester-linked oligomers. Results from this study will facilitate future isolation and characterization of the proteins and enzymes involved in biosynthesis of the SDG-HMG ester-linked oligomers in flax seed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biosynthetic Pathway to the Cancer Chemopreventive Secoisolariciresinol Diglucoside−Hydroxymethyl Glutaryl Ester-Linked Lignan Oligomers in Flax (Linum usitatissimum) Seed

et al. 2001

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“…Therefore, macluraparishins E and C may also be metabolized into 4-HBA, glucose and 3-hydroxy-3methyl-pentane-1,5-dioic acid. The substance 3-Hydroxy-3-methyl-pentane-1,5-dioic acid is known to be a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase and strongly reduces cholesterol, triglycerides, serum β-lipoproteins and phospholipids in vitro and in vivo systems [51,52].…”

Section: Structural Elucidation Of Novel Parishin Compoundsmentioning

confidence: 99%

Identification of Novel Parishin Compounds from the Twig of Maclura tricuspidata and Comparative Analysis of Parishin Derivatives in Different Parts

Kim

Gebru

et al. 2022

Molecules

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Parishin compounds are rare polyphenolic glucosides mainly found in the rhizome of the traditional Chinese medicinal plant, Gastrodia elata. These constituents are reported to have several biological and pharmacological activities. In the present study, two novel parishin derivatives not previously reported as plant-based phytochemicals were identified from a twig of Maclura tricuspidata (MT) and two new compounds were elucidated as 1-(4-(β-d-glucopyranosyloxy)benzyl)-3-hydroxy-3-methylpentane-1,5-dioate (named macluraparishin E) and 1,3-bis(4-(β-d-glucopyranosyloxy)benzyl)-3-hydroxy-3-methylpentane- 1,5-dioate (macluraparishin C), based on the experimental data obtained by UV–Visible (UV–Vis) spectroscopy, high performance liquid chromatography–quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) and nuclear magnetic resonance (NMR) spectroscopy. Additionally, gastrodin, parishin A and parishin B were positively identified by spectroscopic evidence and the comparison of HPLC retention time with the corresponding authentic standards. Gastrodin, parishin A and parishin B, macluraparishin E and macluraparishin C were found to be the most abundant constituents in the MT twig. The compositions and contents of these constituents were found to vary depending on the different parts of the MT plant. In particular, the contents of parishin A, parishin B, macluraparishin C and macluraparishin E were higher in the twig, bark and root than in the leaves, xylem and fruit.

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“…As is known to all, lovastatin is the first approved inhibitor of HMG-CoA reductase in the world, so it was chosen as the positive control in the study (Padova et al, 1982;Tobert, 2003). As shown in Fig.…”

Section: Rt-pcrmentioning

confidence: 99%

Enhancement of the antioxidant and hypolipidemic activities of Puerariae radix by fermentation with Aspergillus niger

Huang

Zhang

Xue

2019

Food Sci Biotechnol

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Puerariae radix (PR) is a traditional Chinese food and medicine. In this study, the chemical profile and bioactivities of PR fermented with Aspergillus niger (PFA) were investigated. Based on HPLC analysis, PFA chemical profile changed and total phenols increased by 12.5% relative to PR. Consequently, the in vitro antioxidant activity significantly improved. According to the blood lipid analysis in mice, PFA showed a better ability to inhibit the increased blood lipid levels induced by Triton WR-1339 than PR. In a quantitative real-time PCR (qRT-PCR) study, PFA up-regulated cholesterol 7-alpha hydroxylase (CYP7A1) and low-density lipoprotein receptor mRNA expression, which were 50% and 44.8% higher than the levels induced by high-dose PR. Conversely, 3-hydroxy-3methylglutaryl-CoA reductase (HMGCoAR) mRNA expression was down-regulated to 46.8% lower than the levels induced by high-dose PR. The qRT-PCR results suggested that PFA displayed better hypolipidemic activity than PR, due to its superior ability to regulate mRNA expression.

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3-hydroxy-3-methylglutaric acid (HMGA) reduces dietary cholesterol induction of saturated bile in hamster

Cited by 12 publications

References 22 publications

Biosynthetic Pathway to the Cancer Chemopreventive Secoisolariciresinol Diglucoside−Hydroxymethyl Glutaryl Ester-Linked Lignan Oligomers in Flax (Linum usitatissimum) Seed

Biosynthetic Pathway to the Cancer Chemopreventive Secoisolariciresinol Diglucoside−Hydroxymethyl Glutaryl Ester-Linked Lignan Oligomers in Flax (Linum usitatissimum) Seed

Identification of Novel Parishin Compounds from the Twig of Maclura tricuspidata and Comparative Analysis of Parishin Derivatives in Different Parts

Enhancement of the antioxidant and hypolipidemic activities of Puerariae radix by fermentation with Aspergillus niger

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