3-Hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats

Yousufzai, Sardar Y.K.; Siddiqi, Majid

doi:10.1007/bf01933955

Cited by 22 publications

(7 citation statements)

References 7 publications

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“…23−26 Studies have shown that HMG can induce dose-dependent hypocholesterolemic effects in animal models, including lowering serum lipids in hyperlipidemic rats similar to SDG. 27,28 In the gastrointestinal tract, the copolymer undergoes hydrolysis to release both SDG and HMG. Therefore, both compounds might contribute to the hypercholesterolemic effects of whole ground flaxseed.…”

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confidence: 99%

Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat

et al. 2021

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Hypercholesterolemia is a risk factor for cardiovascular disease. Conventional treatment methods include lifestyle changes and pharmaceutical interventions, but recently Health Canada approved a health claim for whole ground flaxseed as an alternative treatment for hypercholesterolemia. The literature suggests flaxseed lignans are responsible for the cholesterol-reducing effects of flaxseed. In this study, 96.1% secoisolariciresinol diglucoside (SDG) and a 50% SDG enriched polymer (SDG polymer) were investigated as treatments for hypercholesterolemia in rats. Wistar female rats were fed a 1% high-cholesterol diet for a one-week acclimatization prior to a 23-day intervention with enriched SDG or SDG polymer. A reduction in body weight normalized liver weight was observed in rats treated with enriched SDG when compared to the controls. Both enriched SDG (96.1%) and SDG polymer reduced serum triacylglycerol (19% and 15%, respectively) and increased high-density lipoprotein cholesterol (15% and 24%, respectively). Histopathologic analyses revealed lipid-lowering effects of either enriched SDG or SDG polymer along with lower steatosis scores and nonalcoholic fatty liver disease activity. Furthermore, the lack of statistical significance between SDG and SDG polymer treatment groups suggests that SDG polymer may be a potential alternative to enriched SDG for hypercholesterolemia with similar efficacy but lower cost.

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confidence: 99%

Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat

et al. 2021

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“…Consistent with such findings was the observation that HMGA could shrink atherosclerotic lesions in male albino rabbits (Lupien et al 1973b); unfortunately, such work appears not to have been done in humans. As well, Yousufzai and Siddiqi (1976b) observed aortic arch atheromatous lesion regression in non-diabetic rats as the result of HMGA administration. Such atherosclerosis management is important as atherosclerosis causes myocardial infarction and stroke the two major causes of death in T2D patients (Sasaki et al 1995;Alberti et al 2007;Sharma et al 2017).…”

Section: Hyperglycemiamentioning

confidence: 62%

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes

Barre

Mizier-Barre

2021

Endocrine Regulations

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Objectives. This review assesses the comparative safety and efficacy of selected 3-hydroxy-3-methylglutaric acid coenzyme A inhibitors (statins, cinnamic acids. 3-hydroxy-3-methyl glutaric acid) on the pre-onset type 2 diabetes (PT2D) and post-onset type 2 diabetes (T2D)-related cluster of seven features (central obesity, hyperglycemia, hypertension, dyslipidemia, pro-thrombosis, oxidation and inflammation). Methods. Google scholar and PubMed were searched for statin*, flaxseed lignan complex (FLC), cinnamic acid (CA)*, and 3-hydroxy-3-methylglutaric acid (HMGA) in conjunction with each of PT2D, T2D and the cluster of seven. An introduction was followed by findings or absence thereof on the impacts of each of statins, FLC, CAs and HMGA on each member of the cluster of seven. Results. Pravastatin manages three features in PT2D, while a number of the statins improve five in T2D. FLC is negative in PT2D but controls four in T2D; it is not clear if the CAs and HMGA in FLC play a role in this success. CAs have potential in six and HMGA has potential in three of the cluster of seven though yet CAs and HMGA are untested in PT2D and T2D in humans. There are safety concerns with some statins and HMGA but FLC and CAs appear safe in the doses and durations tested. Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.

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“…In silico studies have also highlighted the α-glucosidase inhibitory properties of catechin [ 37 ]. Further attention can be devoted to meglutol or 3-hydroxy-3-methyl glutaric acid, which is known to induce hypoglycemia and to regulate lipid metabolism [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Phytochemical Composition and Bioactivities of Anacyclus maroccanus Ball. and Anacyclus radiatus Loisel Aerial Parts: Preliminary Evidence for the Possible Development of Moroccan Plants

et al. 2022

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In the present study, the phytochemical composition and bioactivities of A. maroccanus (AM) and A. radiatus (AR), two ecotypes collected in the Demnate road and Essaouira regions, respectively, were studied to highlight a pharmacological interest and to enable possible pharmaceutical development. To this end, methanolic and ethyl acetate extracts were prepared for each ecotype by fractionation; next, their phytochemical composition was evaluated by spectrophotometric and chromatographic analysis. Moreover, in line with the available evidence for Anacyclus spp. and their traditional use, a screening of bioactivities, including antioxidant, hypoglycemic, antiglycative, chelating, and antibacterial activities, was performed. The extracts were characterized by high amounts of polyphenols, tannins, and flavonoids, especially in the methanolic extracts; these samples were also enriched in carotenoids despite a lower chlorophyll content. Chlorogenic acid and rutin were the major identified compounds. The extracts also showed interesting hypoglycemic, antiglycative, and antibacterial properties, although with differences in efficacy and potency. Present results provide more scientific basis to the ethnopharmacological uses of Anacyclus spp. and suggest a further interest in AM and AR ecotypes as natural sources of bioactive compounds and/or phytocomplexes for possible pharmaceutical and nutraceutical developments.

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3-Hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats

Cited by 22 publications

References 7 publications

Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat

Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes

Characterization of the Phytochemical Composition and Bioactivities of Anacyclus maroccanus Ball. and Anacyclus radiatus Loisel Aerial Parts: Preliminary Evidence for the Possible Development of Moroccan Plants

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