3-Fluoropropane-1,2-diol from glycidol (hydroxymethyloxirane)

Fluorocitrate Inhibition of Aconitase: Relative Configuration of Inhibitory Isomer by X-ray Crystallography

“…4.2.1.-16)] from Rhodospirillum rubrum, we found that the combination of PMS and NBT in the presence of threonine also generated a purple precipitant band. Threonine deaminase, purified to homogeneity (5), was subjected to electrophoresis on polyacrylamide gels (Fig. 1).…”

“…itory species. the inThe rubidium ammonium salt of the rocitrate racemate of the diastereoisomer of fluesult of orocitric acid that contains the active s active inhibitor of aconitase was prepared would chemically (5 …”

Synthesis of stereospecifically deuterated fluoroacetic acid and its behaviour in enzymic aldol‐type condensations

“…Fluoroacetyl CoA serves as a substrate analogue both in the citrate synthase and in the malate synthase reactions, It has been established [l] that the former reaction stereospecitically yields (X, 3R)-2-fluorocitrate 1 .Whereas 1 was found to be a powerful inhibitor of aconitase, the enantiomeric (2S, 38)2-fluorocitrate 2 produced by citrate synthase from racemic 3fluorooxalacetate and acetylCoA as well as the synthetically obtained (2R, 3S)-and (2S, 3R)-2-fluorocitrates 3 and 4 were non-inhibitory [2].…”

The crystal structure of rubidium ammonium hydrogen fluorocitrate dihydrate

“…There is only one isomer of fluorocitric acid that is a strong inhibitor of aconitase, and this is the one formed from fluoroacetate by the enzyme citrate (si)-synthase. This isomer has been resolved by Dummel & Kun (1969) from a chemical preparation of fluorocitric acid. In order to determine the absolute configuration of this isomer, crystals of the rubidium ammonium salt were examined.…”