3-Dimensional stable polyelectrolyte hollow capsules: preparation and spontaneous encapsulation

Abstract

By alternatively depositing poly(styrene)-co-poly(acrylic acid) and poly(allylamine hydrochloride) on poly(styrene sulfonate sodium) hybrid CaCO3 microparticles, a series of size-controlled 3-dimensional stable capsules were obtained after the removal of hybrid templates.

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

“…The PAH/PS-PAA multilayer capsules fabricated over PSS-CaCO 3 templates retained their 3D shape even after drying and spontaneously entrapped water-soluble positively charged rhodamine B molecules similar to wet capsules [33]. PAH/PMA capsules fabricated using an alginate-doped CaCO 3 template displayed an interconnected matrix in the interior of hollow capsules, enhancing encapsulation of cationic molecules [34].…”

Inter-protein interactions govern protein loading into porous vaterite CaCO3 crystals

“…27,28 In addition, CaCO 3 crystals can be used as sacrificial templates for the formulation of porous protein 29 and polymer beads, 30,31 and layer-by-layer assemblies to produce multilayer capsules. [32][33][34][35] All these findings indicate that CaCO 3 crystals are promising carriers for the encapsulation of protein-based therapeutics for oral, [36][37][38] intravenous, 17 intratumoral, 39 intranasal, 40 and mucosal drug delivery; 41,42 tissue engineering 43,44 and regeneration; 45,46 and diagnostics. 47,48 This diversity of administration routes enabled by CaCO 3 for protein delivery is especially important because in current medical practice, protein drugs are predominantly available in injectable formulations, but the demand for non-invasive drug delivery systems for therapeutic proteins is high.…”