3-D Choroidal Thickness Maps from EDI-OCT in Highly Myopic Eyes

Ohsugi, Hideharu; Ikuno, Yasushi; Oshima, Kanako; Tabuchi, Hitoshi

doi:10.1097/opx.0b013e3182924017

Cited by 33 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding choroidal thickness, the present findings are in agreement with previous reports describing a thinner choroid in high myopia than in healthy eyes, both subfoveally and in different peripheral locations 2,20,29,30,37 . Besides, whereas in the control group the thickest choroid was found subfoveally, in the myopic group this area was the thinnest.…”

Section: Discussionsupporting

confidence: 93%

Interocular Asymmetry in Choroidal Thickness and Retinal Sensitivity in High Myopia

Alzaben

Cardona

Zapata

et al. 2018

Retina

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Interocular Asymmetry in Choroidal Thickness and Retinal Sensitivity in High Myopia

Alzaben

Cardona

Zapata

et al. 2018

Retina

View full text Add to dashboard Cite

show abstract

“…The observation that foveal RT (measured at the trough of the foveal pit) tends to increase with increasing myopia in our study (although not significantly so), is consistent with previous reports, 18, 37, 38 and is particularly interesting, given that the latter studies also described thinning of the peripheral retina in myopic eyes. Together these data suggest that the central retina is somehow protected against the stretching forces accompanying increased globe expansion, and assumed to underlie the peripheral retinal thinning in myopic eyes.…”

Section: Discussionsupporting

confidence: 94%

“…15, 16 The choroid, a dense vascular structure underlying the retina, plays an important role in meeting the high nutrient and energy demands of the outer retina, with the central avascular foveal region being dependent on the choroid exclusively. In high myopia, the choroid is frequently structurally compromised, with both choroidal neovascularization 16, 17 and chorioretinal atrophy 18 being reported. Previous studies have also shown correlations between axial length and some other ocular parameters, apart from central refractive error, for example, peripapillary retinal nerve fiber layer thickness.…”

mentioning

confidence: 99%

Refractive Error and Ocular Parameters

Ostrin¹,

Yuzuriha²,

Wildsoet³

2015

Optometry and Vision Science

View full text Add to dashboard Cite

Purpose Spectral domain optical coherence tomography (SD-OCT) was used to examine the influence of refractive error (RE) on foveal retinal and choroidal thicknesses and scleral canal width (SCW). The performance of the Cirrus and Bioptigen SD-OCT instruments was compared in the same eyes. Methods Both eyes of forty healthy human subjects, ages 22 to 38 years, were dilated and imaged, with the Cirrus OCT, using 6 mm 5-line rasters collapsed into one line, one centered on the fovea and one bisecting the optic nerve head. Seventy-two of the same eyes were imaged with the Bioptigen OCT, using 6 mm × 6 mm scans, one centered on the fovea and one on the optic nerve head. Subfoveal retinal and choroidal thicknesses and SCW were measured. Axial lengths (AL) and REs were obtained using an IOLMaster and a Grand Seiko autorefractor, respectively. Results Only right eyes were included in analyses. Spherical equivalent REs ranged from −12.18 to +8.12 D (mean: −3.44 ± 4.06 D), and ALs ranged from 20.56 to 29.17 mm (mean: 24.86 ± 1.91 mm). Myopia was associated with relatively thin choroids at the fovea (p<0.05) but normal retinal thickness. SCW was significantly correlated with AL as measured with the Bioptigen OCT (p<0.05). Retinal and choroidal thicknesses recorded with the Bioptigen OCT tended to be smaller than values obtained with the Cirrus OCT (mean difference: 5.63 and 24.76 µm, respectively), while the converse was true for the SCW (mean difference: 25.45 µm). Conclusions The finding that high myopes tend to have a thinner subfoveal choroid is consistent with previous studies. That high myopia was linked to enlarged scleral canals may help to explain the increased risk of glaucoma in myopia. Observed differences obtained with the Cirrus and Bioptigen instruments urge caution in comparing results collected with different instruments.

show abstract

“…Thicker choroidal measurements have been found in central serous chorioretinopathy, Vogt-Koyanagi-Harada disease, multiple evanescent white dot syndrome, adult onset foveomacular vitelliform dystrophy, and macular telangiectasis type 2. 9–13 Thinner choroid thickness measurements have been observed inferior to the optic nerve, 14 in highly myopic eyes, 15 in diabetic eyes, 16,17 and in eyes with reticular pseudodrusen (RPD), also known as subretinal drusenoid deposits (SDDs). 18–21 In age-related macular degeneration, it is the presence of RPD that has been associated with subfoveal and peripapillary choroidal thinning rather than the diagnosis of AMD.…”

mentioning

confidence: 99%

Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging

Zheng

Gregori

Schaal

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PurposeTo analyze the relationship between choroidal thickness and the distribution of choroidal blood vessels in eyes with nonexudative AMD.MethodsEyes with a diagnosis of nonexudative AMD were imaged using a prototype 100-kHz swept-source (SS) optical coherence tomography (OCT) instrument (Carl Zeiss Meditec, Dublin, CA, USA) with a central wavelength of 1050 nm. We used an OCT cube scan pattern consisting of 512 × 512 A-scans over a 12 × 12 mm retinal area. The eyes were partitioned into two groups based on the presence or absence of reticular pseudodrusen (RPD). All scans were segmented using an automated algorithm. In addition, five eyes from each of the two groups were randomly chosen for manual segmentation. Binary choroidal vessels maps were generated from suitable OCT choroidal slabs, and the relationship between the density of large choroidal vessels and choroidal thickness was analyzed using an Early Treatment Diabetic Retinopathy Study–like target centered on the fovea.ResultsTwenty-five eyes were enrolled in each group. The automated algorithm produced accurate choroidal thickness maps with an average difference between the manual and automated segmentations of 13.7 μm. There was a significant and stable correlation between choroidal thickness and choroidal vessel density across the two groups. Both average choroidal thickness and vessel density were significantly lower in eyes with RPD.ConclusionsOur fully automated choroidal segmentation algorithm was able to capture the different patterns of choroidal thickness over a wide area. Choroidal thickness has a clear relationship with the density of large choroid vessels in our sample, irrespective of the presence or absence of RPD.

show abstract

3-D Choroidal Thickness Maps from EDI-OCT in Highly Myopic Eyes

Abstract: Three-dimensional choroidal thickness maps obtained via EDI-OCT are useful for quantifying choroid thickness in subjects with high myopia more accurately.

Cited by 33 publications

References 26 publications

Interocular Asymmetry in Choroidal Thickness and Retinal Sensitivity in High Myopia

Interocular Asymmetry in Choroidal Thickness and Retinal Sensitivity in High Myopia

Refractive Error and Ocular Parameters

Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging

Contact Info

Product

Resources

About