3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells

Vital, Patrik da Silva; Bonatelli, Murilo; Dias, Marina Pereira; Salis, Larissa Vedovato Vilela de; Pinto, Mariana Tomazini; Baltazar, Fátima; Maria‐Engler, Silvya Stuchi; Pinheiro, Céline

doi:10.3390/ijms232415650

Cited by 3 publications

(1 citation statement)

References 86 publications

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“…In Figures S2 A‒S2D, our study found that GL-V9 had superior inhibitory effects on cell growth and glycolytic capacity compared to 3-bromopyruvate (3-BP), a potent HKII inhibitor. 72 , 73 The inhibitory effects of 3-BP are diminished by the increased expression of AKT, and the combination of GL-V9 and 3-BP resulted in much stronger apoptosis of PCa cells than either treatment alone ( Figures S2 E‒S2F).…”

Section: Discussionmentioning

confidence: 99%

GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism

Wang,

Min,

Guo

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism

Wang,

Min,

Guo

et al. 2024

iScience

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Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets

Wang

Deng

et al. 2023

Front. Immunol.

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Cellular metabolism plays a central role in the regulation of both innate and adaptive immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or death. The intricate interplay between metabolism and immune response is critical for maintaining homeostasis and effective antiviral activities. In recent years, immunometabolism induced by viral infections has been extensively investigated, and accumulating evidence has indicated that cellular metabolism can be hijacked to facilitate viral replication. Generally, virus-induced changes in cellular metabolism lead to the reprogramming of metabolites and metabolic enzymes in different pathways (glucose, lipid, and amino acid metabolism). Metabolic reprogramming affects the function of immune cells, regulates the expression of immune molecules and determines cell fate. Therefore, it is important to explore the effector molecules with immunomodulatory properties, including metabolites, metabolic enzymes, and other immunometabolism-related molecules as the antivirals. This review summarizes the relevant advances in the field of metabolic reprogramming induced by viral infections, providing novel insights for the development of antivirals.

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Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

Cunha,

Silva,

Sarmento

et al. 2023

Pharmaceutics

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The “Warburg effect” consists of a metabolic shift in energy production from oxidative phosphorylation to glycolysis. The continuous activation of glycolysis in cancer cells causes rapid energy production and an increase in lactate, leading to the acidification of the tumour microenvironment, chemo- and radioresistance, as well as poor patient survival. Nevertheless, the mitochondrial metabolism can be also involved in aggressive cancer characteristics. The metabolic differences between cancer and normal tissues can be considered the Achilles heel of cancer, offering a strategy for new therapies. One of the main causes of treatment resistance consists of the increased expression of efflux pumps, and multidrug resistance (MDR) proteins, which are able to export chemotherapeutics out of the cell. Cells expressing MDR proteins require ATP to mediate the efflux of their drug substrates. Thus, inhibition of the main energy-producing pathways in cancer cells, not only induces cancer cell death per se, but also overcomes multidrug resistance. Given that most anticancer drugs do not have the ability to distinguish normal cells from cancer cells, a number of drug delivery systems have been developed. These nanodrug delivery systems provide flexible and effective methods to overcome MDR by facilitating cellular uptake, increasing drug accumulation, reducing drug efflux, improving targeted drug delivery, co-administering synergistic agents, and increasing the half-life of drugs in circulation.

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3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells

Cited by 3 publications

References 86 publications

GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism

GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism

Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets

Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

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