3-Bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian

Lu, Zhenyu; Ding, Yuanqing; Li, Xing Cong; Djigbenou, Daignon R.; Grimberg, Brian T.; Ferreira, Daneel; Ireland, Chris M.; Wagoner, Ryan M. Van

doi:10.1016/j.bmc.2011.05.046

Cited by 15 publications

(11 citation statements)

References 22 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3-Bromohomofascaplysin A 1172, homofascaplysin A 803,804 and fascaplysin 805 (Didemnum sp., Pratt Reef, Fiji) are potent growth inhibitors of all life stages of a multiple drug resistant strain of P. falciparum, with homofascaplysin A being particularly potent towards ring stage parasites. 806 The absolute congurations of 1172 and homofascaplysin A were determined by comparison of calculated vs. experimental ECD data.…”

Section: Tunicates (Ascidians)mentioning

confidence: 99%

Marine natural products

et al. 2013

View full text Add to dashboard Cite

This review covers the literature published in 2011 for marine natural products, with 870 citations (558 for the period January to December 2011) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1152 for 2011), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Tunicates (Ascidians)mentioning

confidence: 99%

Marine natural products

et al. 2013

View full text Add to dashboard Cite

show abstract

“…3-Bromohomofascaplysin A (16) ( Fig. 3), a new fascaplysin analog, was isolated together with previously reported non-brominated derivatives from an unidentified Fijian Didemnum tunicate, collected by scuba divers from Pratt Reef, Fiji Islands (Lu et al, 2011). Their structures were elucidated by spectral methods.…”

Section: Figmentioning

confidence: 93%

Ascidian halogen-containing secondary metabolites from the family didemnidae

Djordjevic

Radulović

2019

Facta Univ Phys Chem Technol

View full text Add to dashboard Cite

This review summarizes current knowledge concerning the isolation, structural elucidation, biological/pharmacological activities, and total synthesis of halogen-containing secondary metabolites isolated from ascidians of the family Didemnidae. Overall, 81 compounds are presented, displaying great structural diversity and possessing a number of significant biological/pharmacological properties. In addition to the most numerous brominated compounds, chlorinated and iodinated ones were also found. The most prolific genus in regard to the number of published papers and isolated molecules is the genus Didemnum, which was treated separately from the rest of the genera of the ascidian family. The structural complexity of the isolated metabolites prompted a number of synthetic endeavors that not only provided conclusive proof of the structure of the metabolites but also enabled the biological tests and the possible application of these metabolites.

show abstract

“…Compound 199 displayed an IC 50 of 0.55 ± 0.11 nM versus ring-stage parasites and 105 ± 38 nM versus all live parasites. Therefore, 199 represents a potential agent against drug-resistant malaria [79]. Mollamide B (123) showed a moderate anti-malarial activity versus P. falciparum (D6 clone and W2 clone), with IC 50 values of 0.28 and 3.0 µM, respectively.…”

Section: Compounds With Antiviral Activitiesmentioning

confidence: 99%

Secondary Metabolites of the Genus Didemnum: A Comprehensive Review of Chemical Diversity and Pharmacological Properties

et al. 2020

View full text Add to dashboard Cite

Tunicates (ascidians) are common marine invertebrates that are an exceptionally important source of natural products with biomedical and pharmaceutical applications, including compounds that are used clinically in cancers. Among tunicates, the genus Didemnum is important because it includes the most species, and it belongs to the most speciose family (Didemnidae). The genus Didemnum includes the species D. molle, D. chartaceum, D. albopunctatum, and D. obscurum, as well as others, which are well known for their chemically diverse secondary metabolites. To date, investigators have reported secondary metabolites, usually including bioactivity data, for at least 69 members of the genus Didemnum, leading to isolation of 212 compounds. Many of these compounds exhibit valuable biological activities in assays targeting cancers, bacteria, fungi, viruses, protozoans, and the central nervous system. This review highlights compounds isolated from genus Didemnum through December 2019. Chemical diversity, pharmacological activities, geographical locations, and applied chemical methods are described.

show abstract

3-Bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian

Cited by 15 publications

References 22 publications

Marine natural products

Marine natural products

Ascidian halogen-containing secondary metabolites from the family didemnidae

Secondary Metabolites of the Genus Didemnum: A Comprehensive Review of Chemical Diversity and Pharmacological Properties

Contact Info

Product

Resources

About