3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and Reactions with Binucleophiles Targeting Heterocycles

Abstract

In this review, we reported the synthetic method used to construct thirteen derivatives of 3-aryl/heteryl-2-cyanoacryloyl chloride followed by a focused survey on their spectral data and the synthetic importance of this scaffold for building a wide variety of heterocyclic skeletons using three different types of bidentate nucleophiles.

Synthesis, In vitro Antiproliferative and Antibacterial Evaluation and Molecular Docking Studies of 6-Chloro-3,4-Dihydro-4-Oxo-2H-Chromen-3-yl Methylene-2-Cyano-3-Phenyl Acryloyl Hydrazide

“…1-2 More than 90% of pharmacophoric moieties are reported to have one or more heteroatoms like oxygen, sulphur, nitrogen, and the halogens in their structure. 3 Heterocyclic compounds are of great significance to the medicinal chemists owing to their numerous biological activities. A great deal of heterocyclic compounds with significant biological activity have been developed by researchers.…”