3-Amino- and 5-Aminopyrazoles with Anticonvulsant Activity

Abstract

New 3‐amino‐ and 5‐aminopyrazoles were synthesised. 3‐Aminopyrazoles exert a strong anticonvulsant effect. 4‐Chlorophenyl‐3‐( morpholin‐4‐yl)‐1H‐pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.

Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide

“…All drugs were added to the bath solution (PSS). [21][22][23]. XE991 was purchased from Ascent Scientific (Bristol, UK) or Tocris (Bristol, UK).…”

Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity

“…6.1.8. General procedure for the synthesis of 1-(2 0 ,4 0 -di substituted acridin-9 0 -yl)-3-methyl pyrazol-5-one (7)(8)(9)(10)(11)(12) A mixture of compounds 1-6 (0.01 mol) and ethyl acetoacetate (0.01 mol) was refluxed in methanol (25 mL), containing concentrated hydrochloric acid (1 mL) for 10-15 h on a water bath. The resulting solution was then concentrated and cooled at room temperature.…”

“…The development of NSAIDs has helped in understanding the tissue mechanism of inflammation. The pyrazolines have been gaining prominence due to the fact that its derivatives have been found to possess wide spectrum of activities like anti-inflammatory [3][4][5][6][7], analgesic [7] and anticonvulsant [8,9]. In addition various heterocyclic compounds containing acridinyl moieties [10] were also possess quite interesting anti-inflammatory activity.…”

Synthesis and Characterization of New N‐Pyrazol‐5‐yl) amidine Derivatives: X‐Ray Structure Hirshfeld Surface, and DFT Analyses together with Antibacterial and Antifungal Activity Studies

“…They also affect the intestinal flora and may be considered as a means of fight against phytopathogenic fungi. Therefore agricultural application but also may indirectly affect humans ‘anticonvulsant [23] . Moreover, they are used as antitumor and anti‐HCV, [24] antifungal and antibacterial agents [25] .…”

“…Therefore agricultural application but also may indirectly affect humans 'anticonvulsant. [23] Moreover, they are used as antitumor and anti-HCV, [24] antifungal and antibacterial agents. [25] They were used as a potent corticotrophin-releasing factor-1 (CRF-1) receptor antagonist [26] and biological.…”