3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated fromLonchocarpus AraripensisBenth. (Fabaceae), Reduces Nociceptive Behaviour in Mice

Abstract

Lonchocarpus araripensis Benth. is largely distributed in the northeast region of Brazil. It is popularly known as 'sucupira'. Recent studies have shown that some species of Lonchocarpus have interesting pharmacological activities. In this study, we evaluated the antinociceptive effect of a flavone isolated from L. araripensis. The chemical examination resulted in the isolation of 3,6-dimethoxy-6″,6″-dimethyl-(7,8,2″,3″)-chromeneflavone (DDF). The structure of the compound was established by spectral analysis. Antinociceptive activity of DDF was evaluated by measuring nociception by acetic acid, formalin and hot plate tests. The rota rod test was used to evaluate motor coordination. The results demonstrated that DDF was able to prevent acetic-acid-writhing-induced nociception (p < 0.001) in mice. Furthermore, DDF produced a significant reduction of the nociceptive behaviour at the early and late phases of paw licking in the formalin test. Also, DDF produced an inhibition of the nociceptive behaviour during a hot-plate test. No alteration in motor coordination was observed. These results confirm the hypothesis that DDF reduces the nociceptive behaviour in mice, probably through central mechanisms, but without compromising the motor coordination of animals.

Allelopathy of Dahlstedtia araripensis on Calotropis procera and Zea mays

“…Among the phenolic compounds belonging to the class of flavonoids, the phytochemical prospection of extracts revealed the presence of catechins, chalcones, aurones, flavones, flavonols, xanthones, flavonones, flavononols and leucoanthocyanidins (Table 3). Studies on the phytochemical prospection of plant extracts of D. araripensis showed the presence of flavonoid substances (chalcones, flavones and flavanones) from researches with different parts of the plant (Lima, 2007;Almeida et al, 2015), corroborating with the results found in this study.…”

Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

“…Natural compounds have been used for different therapeutic applications, including antinociceptive (Almeida et al, 2015;Bonjardim et al, 2011;Franco et al, 2011;Melo et al, 2014), antioxidant (Paixão et al, 2013), and antiinflammatory (Veras et al, 2013;Paixão et al, 2015) activities. However, there are few studies that describe pharmacological effects of a nanostructured gel of thymol in acute periodontitis model.…”