3:50 PM Abstract No. 395 Comparison of alcohol ablation and radiofrequency ablation for treatment of hepatocellular carcinoma: A retrospective analysis of long-term overall and disease-free survival

Abstract

ablation site recurrence, three were successfully retreated (primary efficacy rate 76%; assisted efficacy rate 85%). Median disease free survival was 4.5 months (95%-CI 2.8-6.1 months); first site of disease recurrence was liver (n ¼ 11), lung (n ¼ 3), liver & lung (n ¼ 11), intestines (n ¼ 2), peritoneal deposits (n ¼ 3), bone (n ¼ 2), and brain (n ¼ 1). Median overall survival was not reached; one-year overall survival was 78%. Conclusions: IRE represents a safe and effective technique for patients with small CRLM (3.5 cm) that are unsuitable for surgery and thermal ablation. Although the outcome regarding local tumor control appears to be promising, the relatively high number of early distant site recurrences should keep us wary. The results mandate the setup of a trial comparing IRE to stereotactic ablative radiotherapy (SABR) for CRLM unsuitable for surgery and thermal ablation (COLDFIRE-3).