3.5-GHz radiofrequency electromagnetic radiation promotes the development of Drosophila melanogaster

Wang, Yahong; Jiang, Zhihao; Zhang, Lu; Liao, Yulin; Cai, Peng

doi:10.1016/j.envpol.2021.118646

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…Information about the effects of EMF on the arthropod nervous system is scarce. In previously published papers on drosophila, it is suggested that EMFs can affect the signaling pathways in ecdysteroid production [50] and the levels of biogenic amines in the brain [23]. Changes in biogenic amine levels after low-frequency irradiation were found in crickets as well [55].…”

Section: Discussionmentioning

confidence: 97%

“…Modulation, pulsed fields, intensity, and specific absorption rate have been cited as factors that enhance the biological effects of exposure [49]. In the irradiation study on drosophila, all intensities (power densities) produced a change in gene expression and enzyme activity after Pathogens 2023, 12, 1398 9 of 13 48 h exposure, and it seems that there is still bioactive effect if the irradiation is less than 0.0613 V/m [50]. The effect of radiation, according to studies, is most noticeable from 30 cm distance but can still have an effect from a 1 m distance, especially if the power density is higher than 1 µW/cm [49].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Electromagnetic Radiation on Neuropeptide Transcript Levels in the Synganglion of Ixodes ricinus

Šofranková,

Baňas,

Pipová

et al. 2023

Pathogens

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Anthropogenic electromagnetic radiation is an important environmental factor affecting the functionality of biological systems. Sensitivity to various frequencies of electromagnetic radiation has been detected in ixodid ticks in the past. However, the physiological aspects of radiation effects have not yet been studied in ticks. In the presented experiment, 360 Ixodes ricinus ticks, 180 males and 180 females, were divided into 16 irradiated and 8 control groups. The irradiated groups were exposed to two different intensities of electromagnetic radiation with a frequency of 900 MHz at different lengths of exposure time. RT-PCR was utilized to determine the changes in mRNA levels in tick synganglia after irradiation. Four randomly selected neuropeptide genes were tested—allatotropin (at), FGLa-related allatostatins (fgla/ast), kinin, and arginine-vasopressin-like peptide (avpl). A significant decrease in transcript levels in all female groups exposed to higher intensity radiofrequency radiation for 1 to 3 h was found. After one hour of radiofrequency exposure, a significant downregulation in allatotropin expression in males was detected. A consistent downregulation of the at gene was detected in males irradiated with at a higher intensity. Unfortunately, the specific functions of the studied neuropeptides in ticks are not known yet, so a more comprehensive study is necessary to describe the effects of EMF on observed neuropeptides. This study represents the first report on the effects of the abiotic environment on tick neurophysiology.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Effects of Electromagnetic Radiation on Neuropeptide Transcript Levels in the Synganglion of Ixodes ricinus

Šofranková,

Baňas,

Pipová

et al. 2023

Pathogens

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“…Whether these effects are still measurable using SAR levels complying with the guidelines remains to be determined. Wang et al assessed the impact of short- and long-term exposures using unmodulated 3.5 GHz RF-EMF at three different SAR (2.6, 26, and 260 mW/kg) on Drosophila melanogaster 9 , 10 . These authors showed a moderate but significant impact on insect activity, sleep, and development that was accompanied by a modification in the expression of genes involved in circadian rhythms, thermal stress, oxidative stress, and humoral immunity.…”

Section: Introductionmentioning

confidence: 99%

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells

Joushomme

Orlacchio

Patrignoni

et al. 2023

Sci Rep

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The potential health risks of exposure to radiofrequency electromagnetic fields from mobile communications technologies have raised societal concerns. Guidelines have been set to protect the population (e.g. non-specific heating above 1 °C under exposure to radiofrequency fields), but questions remain regarding the potential biological effects of non-thermal exposures. With the advent of the fifth generation (5G) of mobile communication, assessing whether exposure to this new signal induces a cellular stress response is one of the mandatory steps on the roadmap for a safe deployment and health risk evaluation. Using the BRET (Bioluminescence Resonance Energy-Transfer) technique, we assessed whether continuous or intermittent (5 min ON/ 10 min OFF) exposure of live human keratinocytes and fibroblasts cells to 5G 3.5 GHz signals at specific absorption rate (SAR) up to 4 W/kg for 24 h impact basal or chemically-induced activity of Heat Shock Factor (HSF), RAt Sarcoma virus (RAS) and Extracellular signal-Regulated Kinases (ERK) kinases, and Promyelocytic Leukemia Protein (PML), that are all molecular pathways involved in environmental cell-stress responses. The main results are (i), a decrease of the HSF1 basal BRET signal when fibroblasts cells were exposed at the lower SARs tested (0.25 and 1 W/kg), but not at the highest one (4 W/kg), and (ii) a slight decrease of As2O3 maximal efficacy to trigger PML SUMOylation when fibroblasts cells, but not keratinocytes, were continuously exposed to the 5G RF-EMF signal. Nevertheless, given the inconsistency of these effects in terms of impacted cell type, effective SAR, exposure mode, and molecular cell stress response, we concluded that our study show no conclusive evidence that molecular effects can arise when skin cells are exposed to the 5G RF-EMF alone or with a chemical stressor.

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“…Among these, the exposure of zebrafish embryos at specific absorption rate (SAR) of 8.27 W/kg induced depressed sensorimotor function, abnormal behavioral responses, and variations in the expression of genes related to metabolic function in adult zebrafish (Dasgupta et al, 2020(Dasgupta et al, , 2022. In Drosophila melanogaster, 3.5 GHz exposure enhanced the expression of heat shock, oxidative stress, and humoral immunity system genes leading to fly developmental promotion (Wang et al, 2022). In addition, longterm exposure resulted in alterations of the expression of circadian clock genes resulting in improvement of sleep duration (Wang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Patrignoni,

Hurtier,

Orlacchio

et al. 2023

Bioelectromagnetics

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Whether human cells are impacted by environmental electromagnetic fields (EMF) is still a matter of debate. With the deployment of the fifth generation (5G) of mobile communication technologies, the carrier frequency is increasing and the human skin becomes the main biological target. Here, we evaluated the impact of 5G‐modulated 3.5 GHz radiofrequency (RF) EMF on mitochondrial stress in human fibroblasts and keratinocytes that were exposed for 24 h at specific absorption rate of 0.25, 1, and 4 W/kg. We assessed cell viability, mitochondrial reactive oxygen species (ROS) production, and membrane polarization. Knowing that human skin is the main target of environmental ultraviolet (UV), using the same read‐out, we investigated whether subsequent exposure to 5G signal could alter the capacity of UV‐B to damage skin cells. We found a statistically significant reduction in mitochondrial ROS concentration in fibroblasts exposed to 5G signal at 1 W/kg. On the contrary, the RF exposure slightly but statistically significantly enhanced the effects of UV‐B radiation specifically in keratinocytes at 0.25 and 1 W/kg. No effect was found on mitochondrial membrane potential or apoptosis in any cell types or exposure conditions suggesting that the type and amplitude of the observed effects are very punctual.

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3.5-GHz radiofrequency electromagnetic radiation promotes the development of Drosophila melanogaster

Cited by 12 publications

References 49 publications

Effects of Electromagnetic Radiation on Neuropeptide Transcript Levels in the Synganglion of Ixodes ricinus

Effects of Electromagnetic Radiation on Neuropeptide Transcript Levels in the Synganglion of Ixodes ricinus

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells

Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

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