3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1<i>H</i>)-pyridinone:  Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria L.; Malcolm, Craig S.; Porter, Richard H.

doi:10.1021/jm990945v

Cited by 36 publications

(27 citation statements)

References 22 publications

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“…12 64, 65. The dual-action agents were shown to inhibit lipid peroxidation in rat brain homogenates and protect cells against toxicity induced by ROS-generating iodoacetate 64.…”

Section: Chelator–antioxidant Hybrid Moleculesmentioning

confidence: 99%

“…12 64, 65. The dual-action agents were shown to inhibit lipid peroxidation in rat brain homogenates and protect cells against toxicity induced by ROS-generating iodoacetate 64. Some of the derivatives showed superior neuroprotection compared to dual administration of antioxidants like BHT (butylhydroxytoluene) or Trolox and deferiprone 64…”

Section: Chelator–antioxidant Hybrid Moleculesmentioning

confidence: 99%

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Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

2010

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Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metalchelating agents provide one such function as an intervention for ameliorating metal-associated damage in degenerative diseases. Targeting chelators to adjust localized metal imbalances in the brain, however, presents significant challenges. In this perspective, we focus on some noteworthy advances in the area of multifunctional metal chelators as potential therapeutic agents for neurodegenerative diseases. In addition to metal chelating ability, these agents also contain features designed to improve their uptake across the blood-brain barrier, increase their selectivity for metals in damage-prone environments, increase antioxidant capabilities, lower Aβ peptide aggregation, or inhibit disease-associated enzymes such as monoamine oxidase and acetylcholinesterase.

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“…12 64, 65. The dual-action agents were shown to inhibit lipid peroxidation in rat brain homogenates and protect cells against toxicity induced by ROS-generating iodoacetate 64.…”

Section: Chelator–antioxidant Hybrid Moleculesmentioning

confidence: 99%

Section: Chelator–antioxidant Hybrid Moleculesmentioning

confidence: 99%

Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

2010

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“…Connecting together the features of different natural antioxidants is a modern trend in drug discovery [28]. In fact, small molecules that protect against ROS face the problem that any new radical formed, even when stabilized, retains a prooxidant effect [29], that is, the possibility of damaging the tissue where it was generated.…”

Section: Resultsmentioning

confidence: 99%

Ortho‐thioquinones and mediterranean diet: The sulfur connection

Menichetti¹,

Pagliuca²,

Viglianisi³

2007

Heteroatom Chemistry

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] For example, hdmp ( Fig. 1) has found moderate success in chelation therapy for the treatment of iron-overload in humans.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and hydroboration of lipophilic hydroxy-pyridinones and their complexes with molybdenum(VI)

Gagnon¹,

Germain²,

Vogels³

et al. 2000

Aust. J. Chem.

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We have prepared four potentially lipophilic N-substituted hydroxypyridinones containing unsaturated hydrocarbon groups. The propyl vinyl ether derivative (3) has been characterized by an X-ray diffraction study. Complexes of the type cis-MoO2L2, where L represents the hydroxypyridinonato ligands, have also been prepared. The pyridinone ligands are bound to molybdenum in a cis bidentate fashion via the deprotonated hydroxy groups and the ketone moieties. Initial investigations into the hydroboration of the alkene groups in the pyridinone ligands and corresponding metal complexes is presented. Crystals of (3) are monoclinic, with a 10.466(1), b 13.388(1), c 15.386(2) Å, β 102.343(8)˚, Z 8, space group P21/n.

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3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

Cited by 36 publications

References 22 publications

Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Ortho‐thioquinones and mediterranean diet: The sulfur connection

Synthesis and hydroboration of lipophilic hydroxy-pyridinones and their complexes with molybdenum(VI)

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