3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Rocha, Fábio R.P.; Barra, Vincent; Netto, Adelino Vieira de Godoy; Mauro, Antônio Eduardo; Carlos, Iracilda Zeppone; Frem, Regina Célia Galvão; Ananias, Sandra R.; Quilles, Marcela B.; Stevanato, Alessandra; Rocha, Michelle C.

doi:10.1016/j.ejmech.2009.12.073

Cited by 49 publications

(10 citation statements)

References 30 publications

(41 reference statements)

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“…Supramolecular coordination chemistry of aromatic polyoxalamide ligands: A metallosupramolecular approach toward functional magnetic materials. Coordination Chemistry Reviews, 254 (19)(20), 2281-96.…”

Section: Thermal Behavior Studiesmentioning

confidence: 99%

Studies on the Thermal Behavior of Polynuclear Palladium(ii) Compounds Containing Pyrazolato Ligands

Silva¹,

Mauro²,

Frem³

et al. 2019

Braz. J. Therm. Anal

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The synthesis, spectroscopic characterization and thermal behavior of the pyrazolate-bridged palladium complexes [Pd3(µ-N3)(µ-Pz)5]n (1), [Pd3(µ-N3)(µ-mPz)5]n (2), [Pd3(µ-N3)(µ-IPz)5]n (3), [Pd6(µ-N3)2(µ-Pz)5(µ-mPz)5]n (4), [Pd6(µ-N3)2(µ-Pz)5(µ-dmPz)5]n (5) and [Pd6(µ-N3)2(µ-Pz)5(µ-IPz)5]n (6) {pyrazolate (Pz -), 4-methylpyrazolate (mPz -), 3,5-dimethylpyrazolate (dmPz -), 4-iodopyrazolate (IPz -)} have been described in this work. The thermal decomposition of the compounds occurs in four or five stages and the final decomposition residues were identified as metallic palladium using X-ray powder diffraction method. TG studies showed that the introduction of substituted pyrazolato groups in the composition of the polynuclear compounds affect significantly their thermal stability. It can be concluded that the presence of pyrazolato ligands containing methyl or iodine groups at the 4 position has a crucial effect on the thermal stability of the polynuclear compounds described in this work.

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Section: Thermal Behavior Studiesmentioning

confidence: 99%

Studies on the Thermal Behavior of Polynuclear Palladium(ii) Compounds Containing Pyrazolato Ligands

Silva¹,

Mauro²,

Frem³

et al. 2019

Braz. J. Therm. Anal

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“…Special attention is paid to platinum complexes with different structural features from those of in-use drugs and complexes of other platinum-group metals like ruthenium, rhodium, palladium, and iridium (7,8). On the basis of the structural and thermodynamic analogy between platinum (II) and palladium (II) complexes, there is also much interest in the study of palladium(II) derivatives as potential anticancer drugs (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Binding Behavior between the S-heterocyclic Aromatic Palladium(II) Complex and Human Serum Albumin: Spectroscopic Approach

Saeidifar

Khanlarkhani

Eslami-Moghaddam

et al. 2015

Polycyclic Aromatic Compounds

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The interaction of 1, 10-phenanthroline octhyldithiocarbamato palladium(II) nitrate ([Pd(Oct-dtc)(phen)]NO 3 ) with human serum albumin (HSA) has been investigated by various spectroscopic techniques under physiological conditions. Here, HSA was titrated with the Pd(II) complex, followed by UV-Vis absorption spectroscopy to estimate a binding constant (K b ) and other thermodynamic parameters. The results indicate that the Pd (II) complex has a high affinity for bind HSA. Thermodynamic analysis showed that the enthalpy ( H • ) and entropy changes ( S • ) are positive and Gibbs free energy change ( G • ) is negative which indicated that hydrophobic interactions played the predominant role in the binding process. Fluorescence spectroscopy were used to show the mechanism and binding parameters of this interaction. Utilizing the Stern-Volmer equation, the Pd(II) complex quenched the intrinsic fluorescence of HSA via a static quenching procedure. The specific binding distances between the tryptophan (donor) proteins and Pd(II) complex (acceptor) were estimated by Forster resonance energy transfer. The CD results also showed the conformational changes on serum albumin upon binding with the Pd(II) complex.

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“…In the framework of our current research on the coordination and biological chemistry of transition metal compounds [19][20][21][22][23][24], we describe in the present paper the synthesis, spectroscopic data and X-ray crystallographic studies on the organometallic compound [Pd(C-bzan)(SCN)(dppp)] {bzan = N-benzylideneaniline, dppp = 1,3-bis(diphenylphosphino)propane}, and evaluated its antimycobacterial activity against TB bacillus.…”

mentioning

confidence: 99%

“…One challenging task for medicinal chemists in the discovery of new drugs for tuberculosis treatment is to obtain antimycobacterial agents which can easily penetrate the highly impermeable bacterial cell wall. In this perspective, Pd(II) complexes containing diphosphine ligands could represent an interesting strategy in the design of new compounds with enhanced activity against M. tuberculosis.In the framework of our current research on the coordination and biological chemistry of transition metal compounds [19][20][21][22][23][24], …”

mentioning

confidence: 99%

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Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

Ferreira

Stevanato

Santana³

et al. 2012

Inorganic Chemistry Communications

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3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Cited by 49 publications

References 30 publications

Studies on the Thermal Behavior of Polynuclear Palladium(ii) Compounds Containing Pyrazolato Ligands

Studies on the Thermal Behavior of Polynuclear Palladium(ii) Compounds Containing Pyrazolato Ligands

Investigation of the Binding Behavior between the S-heterocyclic Aromatic Palladium(II) Complex and Human Serum Albumin: Spectroscopic Approach

Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

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