3,5-Bis(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

Abstract

In the title compound, C21H16Br2N2, the central pyrazole ring adopts an flattened envelope conformation, with the stereogenic C atom in the flap position. The deviations from planarity for this ring are relatively minor (r.m.s. deviation = 0.045 Å) and the dihedral angles formed with the N- and Cimine-bound benzene rings are 7.73 (13) and 11.00 (13)°, respectively. By contrast, the benzene ring bound at the chiral C atom is almost orthogonal to the rest of the mol­ecule; the dihedral angle formed between this ring and the pyrazole ring is 79.53 (13)°. In the crystal, the packing is stabilized by C—H⋯N and C—H⋯Br inter­actions.

5-(4-Bromophenyl)-3-(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

“…For background to pyrazoline derivatives, see: Fun et al (2010); Samshuddin et al (2010Samshuddin et al ( , 2011. For a related structure, see: Samshuddin et al (2010).…”

“…Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009 In continuation of our work on synthesis of pyrazoline derivatives (Fun et al, 2010;Samshuddin et al, 2010Samshuddin et al, , 2011, the title compound was prepared and its crystal structure is now reported.…”

“…For a related structure, see: Samshuddin et al (2010). For the stability of the temperature controller used in the data collection, see : Cosier & Glazer (1986 Table 1 Hydrogen-bond geometry (Å , ).…”

(2E)-1-(3,4-Dichlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one

“…For the synthesis of chalcone derivatives, see: Samshuddin et al (2010;Fun et al (2010); Jasinski et al (2010); Baktır et al (2011). For related structures, see: Fun et al (2011);Jasinski et al (2011).…”

(2E)-3-(6-Methoxynaphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one and its cyclocondensation product with guanidine, (4RS)-2-amino-4-(6-methoxynaphthalen-2-yl)-6-(pyridin-3-yl)-3,4-dihydropyrimidine monohydrate: two types of hydrogen-bonded sheet

“…Thus, for example, the cyclocondensation reactions of chalcones with simple hydrazines lead to the formation of dihydropyrazole derivatives (Fun et al, 2010;Jasinski, Guild et al, 2010;Jasinski, Pek et al, 2010;Samshuddin et al, 2010). Following these precedents, we have now prepared the title dihydropyrimidine derivative (4RS)-2-amino-4-(6-methoxynaphthalen-2-yl)-6-(pyridin-3-yl)-3,4-dihydropyrimidine monohydrate, (II) (Fig.…”