(±)3,4-Methylenedioxymethamphetamine, d-Amphetamine, and Cocaine Impair Delayed Matching-to-Sample Performance by an Increase in Susceptibility to Proactive Interference.

Harper, David N.; Wisnewski, Regan G.; Hunt, Maree; Schenk, Susan

doi:10.1037/0735-7044.119.2.455

Cited by 45 publications

(101 citation statements)

References 56 publications

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“…The rapid decline in log d over delay intervals lasting several seconds in the present study is consistent with numerous DMTS studies in pigeons (for a recent review see White, 2013), rats (Harper et al, 2005), nonhuman primates (Wright, Urcuioli, and Sands, 1986), and humans (Williams, Johnston, and Saunders, 2006). Furthermore, log d showed a consistent delay interval-dependent decrease across repeated tests and typically decreased to near chance levels within 10 seconds.…”

Section: Discussionsupporting

confidence: 91%

Effects of environmental and pharmacological manipulations on a novel delayed nonmatching-to-sample ‘working memory’ procedure in unrestrained rhesus monkeys

Hutsell

Banks

2015

Journal of Neuroscience Methods

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Background Working memory is a domain of ‘executive function.’ Delayed nonmatching-to-sample (DNMTS) procedures are commonly used to examine working memory in both human laboratory and preclinical studies. New Method The aim was to develop an automated DNMTS procedure maintained by food pellets in rhesus monkeys using a touch-sensitive screen attached to the housing chamber. Specifically, the DNMTS procedure was a 2-stimulus, 2-choice recognition memory task employing unidimensional discriminative stimuli and randomized delay interval presentations. Results DNMTS maintained a delay-dependent decrease in discriminability that was independent of the retention interval distribution. Eliminating reinforcer availability during a single delay session or providing food pellets before the session did not systematically alter accuracy, but did reduce total choices. Increasing the intertrial interval enhanced accuracy at short delays. Acute Δ9-THC pretreatment produced delay interval-dependent changes in the forgetting function at doses that did not alter total choices. Acute methylphenidate pretreatment only decreased total choices. Comparison with existing methods All monkeys were trained to perform NMTS at the 1 s training delay within 60 days of initiating operant touch training. Furthermore, forgetting functions were reliably delay interval-dependent and stable over the experimental period (~6 months). Conclusions Consistent with previous studies, increasing the intertrial interval improved DNMTS performance, whereas Δ9-THC disrupted DNMTS performance independent of changes in total choices. Overall, the touchscreen-based DNMTS procedure described provides an efficient method for training and testing experimental manipulations on working memory in unrestrained rhesus monkeys.

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Section: Discussionsupporting

confidence: 91%

Effects of environmental and pharmacological manipulations on a novel delayed nonmatching-to-sample ‘working memory’ procedure in unrestrained rhesus monkeys

Hutsell

Banks

2015

Journal of Neuroscience Methods

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“…Rats showed impairment on a delayed matching to sample task at low doses of 0.6 and 1.0 mg/kg amphetamine, i.p. (Harper et al 2005). At these doses, the responses rats gave for a given trial were greatly influenced by their responses from the preceding trial.…”

Section: Discussionmentioning

confidence: 97%

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Wood

Anagnostaras

2008

Psychopharmacology

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Rationale and Objectives-With prescriptions of stimulants on the rise, it is important to examine the cognitive effects of low and moderate doses of stimulants, rather than only those typical of addicts.Methods-The present study examined the effects a range of doses (0.005 -8 mg/kg) of damphetamine sulfate on cued and contextual Pavlovian fear conditioning in mice.Results-In agreement with previous research, subjects administered a moderately high dose of amphetamine (8 mg/kg) pre-training, typical of what addicts might take, displayed impaired memory when tested, off-drug. Alternately, subjects injected with a very low dose of amphetamine (0.005, 0.025, or 0.05 mg/kg), pre-training, similar to the therapeutic doses for attention deficit hyperactivity disorder, displayed enhanced memory when tested, off-drug. A control study showed these effects were not due to state-dependent learning.Conclusions-Thus, dose is a critical determinant of the cognitive effects of psychostimulants.

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“…The conclusions of the above studies were that acute MDMA results in working memory impairments. However, it has been argued that these findings do not involve working memory effects, but rather reflect disruptions of reference memory involving the rules or strategies associated with a given task (Harper et al, 2005; 2006; Kay et al, 2010). As an illustration, Kay et al (2010) used a version of the radial arm maze designed to separate working and reference memory and found that MDMA had no effect on the working memory task (arms were always baited for one visit), but impaired the reference memory task (arms that were never baited throughout the experiment).…”

Section: Discussionmentioning

confidence: 99%

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

et al. 2014

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Acute effects of methylenedioxymethamphetamine (MDMA), methamphetamine (MA) and methylphenidate (MPD) were studied using a within-subject, repeated acquisition/performance procedure adapted to the Morris Swim Task. To investigate place learning, the acquisition component consisted of a hidden platform that varied in location across experimental sessions. As a control for drug effects not specific to acquisition, a performance component was included in which the hidden platform was in the same pool location in every experimental session. All three drugs increased escape latencies and swim distances in dose-dependent fashion. However, impairment in the acquisition component was generally observed only at doses that also produced impairment in the performance component, suggesting that effects were not selective to place learning. None of the drugs produced enhancement of learning or performance at any dose. Taken together, the results suggest that acute exposure to these psychomotor stimulants produce global impairment of performance in the Morris task, rather than specific deficits in place learning.

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(±)3,4-Methylenedioxymethamphetamine, d-Amphetamine, and Cocaine Impair Delayed Matching-to-Sample Performance by an Increase in Susceptibility to Proactive Interference.

Cited by 45 publications

References 56 publications

Effects of environmental and pharmacological manipulations on a novel delayed nonmatching-to-sample ‘working memory’ procedure in unrestrained rhesus monkeys

Effects of environmental and pharmacological manipulations on a novel delayed nonmatching-to-sample ‘working memory’ procedure in unrestrained rhesus monkeys

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

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