3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

“…It may be further surmised that blocking conversion of the aldehyde intermediates to the inactive alcohols or acids would enhance the associated toxicity. This concept is supported by findings that combined inhibition of aldehyde dehydrogenase and aldose or aldehyde reductase in PC12 cells increases production of DOPAL and potentiates the neurotoxic actions of rotenone (Lamensdorf et al, 2000b). Inhibition of MAO blocks this effect, confirming the dependence of the enhanced toxicity on the deamination process.…”

“…6). DOPAL, the deaminated aldehyde metabolite of dopamine, and DOPEGAL, the corresponding metabolite of norepinephrine and epinephrine, are highly toxic in cell CATECHOLAMINE METABOLISM culture systems (Mattammal et al, 1995;Burke et al, 1996;Lamensdorf et al, 2000b;Li et al, 2001), and in vivo in experimental animals . Since most of the monoamine transmitter produced in catecholaminergic nerves is deaminated within the neuronal cytoplasm, the intraneuronal production of DOPAL and DOPEGAL has considerable potential for a significant role in neurodegenerative processes affecting central and peripheral catecholamine neuronal systems.…”

Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans

“…Alternatively, dihidroxyphenylethanol has been identified as a metabolite from dopamine metabolism in dopaminergic cell lines (Lamensdorf et al, 2000). Other in vitro studies have demonstrated the formation of hydroxytyrosol as a result of 3,4-dihidroxyphenylacetaldehyde (DOPAL), a dopamine metabolite, reduction by the human liver alcohol dehydrogenase isoenzyme (Mardh & Vallee, 1986).…”

Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase

“…Nonetheless, a substantial and convincing body of relatively recent evidence does exist, which indicates the toxicity and reactivity of these compounds in the CNS. On the basis of these studies, a role for DOPAL and DOPEGAL in neurodegenerative diseases has been proposed (Mattammal et al, 1995;Lamensdorf et al, 2000b;Burke et al, 2004).…”