2022
DOI: 10.21203/rs.3.rs-2230124/v1
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3,4-benzo[a]pyrene aggravates myocardial infarction injury by activating NLRP3-related pyroptosis through PINK1/Parkin-mitophagy-mPTP opening axis

Abstract: Acute myocardial infarction(AMI) accounts for more than one third of ischemic heart disease deaths. Air pollution exposure,even for a short-term exposure,is conspicuously relevant to increased risk of MI mortality and clinical evidence has showed that air pollution particulate matter(PM) induces the aggravation of AMI.3,4-benzo[a]pyrene(BaP),a polycyclic aromatic hydrocarbon(PAH) with toxicity,is a typical air pollutant present in PM and is often measured as the representative of PAHs.The purpose of this study… Show more

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