3.0‐Tesla MR angiography of intracranial aneurysms: Comparison of time‐of‐flight and contrast‐enhanced techniques

Gibbs, Gordon F.; Huston, John; Bernstein, Matt A.; Riederer, Stephen J.; Brown, Robert D.

doi:10.1002/jmri.20247

Cited by 51 publications

(33 citation statements)

References 9 publications

(13 reference statements)

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“…In another familial IA screening study, 13 of the 43 DS angiograms performed to confirm the MR angiography findings, 7 (16%) of 43 were negative, with the suspected IA later found to be a vessel loop. It is noteworthy that the prior study was performed > 10 years ago and that current MR angiography screening probably has a higher specificity and sensitivity, 5,6 even for very small aneurysms.…”

Section: Discussionmentioning

confidence: 99%

“…The inter-observer agreement in defining IA in asymptomatic patients is excellent, and more recent advances in MR angiography have further improved this interobserver agreement, even among small aneurysms. 5,6 Intraarterial cerebral arteriography remains the gold standard for aneurysm detection, but does entail a low risk of stroke and other complications. Arteriographic confirmation of the aneurysm's presence was not required for the current study.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

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Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Brown

Huston

Hornung

et al. 2008

JNS

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Object-Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies. Methods-TheFamilial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression.Results-Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006).Conclusions-In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening. To clarify further the occurrence of IA detection on brain MR angiography studies in families with several members affected, we report the initial results of MR angiography screening of FDRs-siblings, parents, and children-of those affected with an IA in a multicenter study of familial IA. We also report the predictors of IA detection on brain MR angiography among these FDRs. Clinical Materials and MethodsThe FIA study is an international, multicenter study including 26 clinical centers, which represents 41 recruitment sites in North America, New Zealand, and Australia. 2 The study was approved by the institutional review board/ethics committee at each of the study centers and recruitment sites.Families with multiple members in whom IAs were diagnosed were enrolled to identify the chromosomal regions associated with an increased risk of IA and to determine the effects of environmental factors on the expression of genes within these regions. Individuals with either ruptured or unruptured IAs were considered to have the phenotype. Patients were excluded if they had a fusiform IA; an intranidal aneurysm with an arteriovenous malformation; a family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan syndrome, fibromuscular dysplasia, or moyamoya syndrome; or if informed consent could not be obtained from the patient or family members.Detailed medical records and the informa...

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Section: Discussionmentioning

confidence: 99%

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Brown

Huston

Hornung

et al. 2008

JNS

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100

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“…It has been shown that TOF-MRA is a sensitive and safe technique regarding coiled aneurysms; some authors have concluded that it may be even more sensitive than DSA [5,9,[17][18][19][20][21]. Others recommend CE-MRA or contrastenhanced TOF-MRA to raise sensitivity regarding residual filling and to minimize stent-related artifacts [6,7,9,22,23]. In our relatively small collective, more neck remnants were detected in TOF-MRA than in DSA.…”

Section: Discussionmentioning

confidence: 99%

“…If there is a good correlation with a magnetic resonance angiography (MRA) obtained on the same occasion, follow-up is continued by MRA at regular intervals. With regard to current publications, it is discussed controversially whether TOF-MRA or contrast-enhanced MRA (CE-MRA) is the superior technique for aneurysm follow-up [6,7]. Other authors recommend contrastenhanced TOF-MRA to enhance the sensitivity [8,9].…”

Section: Introductionmentioning

confidence: 99%

No advantage of time-of-flight magnetic resonance angiography at 3 Tesla compared to 1.5 Tesla in the follow-up after endovascular treatment of cerebral aneurysms

et al. 2008

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“…The SNR can be expected to be twice as high at 3.0 T as at 1.5 T. This higher SNR could be theoretically used to obtain higher temporal or spatial resolution imaging or a reduction in scan time. For this reason, 3.0 T imaging has established applications in the neuroradiologic field (25,26). However, there are many problems associated with 3.0 T imaging particularly for the abdomen and pelvis (13,27,28).…”

Section: T Mri Of the Abdomen And Pelvis In Clinical Settingsmentioning

confidence: 99%

MR imaging of endometrial carcinoma for preoperative staging at 3.0 T: Comparison with imaging at 1.5 T

Hori

Kim

Murakami

et al. 2009

Magnetic Resonance Imaging

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Purpose:To prospectively compare magnetic resonance imaging (MRI) at 3.0 T and 1.5 T in the same patients for preoperative evaluation of endometrial carcinoma. Materials and Methods:Thirty consecutive patients with endometrial carcinoma underwent MRI at both 3.0 T and 1.5 T as well as surgery. Quantitative and qualitative analyses were performed. Two radiologists independently evaluated images. MR findings were compared with surgicopathologic findings.Results: Image homogeneity of T2-weighted images at 3.0 T was significantly inferior to that at 1.5 T (P ϭ 0.007). The scores of image homogeneity and susceptibility artifacts were not significantly different between 3.0 T gadoliniumenhanced imaging and 1.5 T imaging (P ϭ 0.09 and 0.36). Kappa statistics showed good interobserver agreement between the two radiologists for local-regional staging on T2-weighted images ( Ͼ0.6). The area under the receiver operating characteristic curve (Az) values for T2-weighted imaging in terms of myometrial invasion, cervical invasion, and lymph node metastases were 0.88 (3.0 T) versus 0.91 (1.5 T), 0.84 versus 0.83, and 0.94 versus 0.95 for reader 1, respectively. There were no significant differences between imaging at 3.0 T and at 1.5 T in Az values for either reader (P Ͼ 0.35).Conclusion: 3.0 T MRI is an equivalent imaging modality to 1.5 T imaging for presurgical evaluation of endometrial carcinoma, although not significantly superior to 1.5 T imaging.

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3.0‐Tesla MR angiography of intracranial aneurysms: Comparison of time‐of‐flight and contrast‐enhanced techniques

Cited by 51 publications

References 9 publications

Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection

No advantage of time-of-flight magnetic resonance angiography at 3 Tesla compared to 1.5 Tesla in the follow-up after endovascular treatment of cerebral aneurysms

MR imaging of endometrial carcinoma for preoperative staging at 3.0 T: Comparison with imaging at 1.5 T

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