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Kaddour, C; Haddad, Z; Baffoun, N.

doi:10.1186/cc4622

Cited by 2 publications

(6 citation statements)

References 2 publications

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“…Individual complications at index pregnancy were relatively more frequent in c-HELLP, probably reflecting greater comorbidity, albeit not reaching statistical significance. Different clinical presenting features and laboratory values that reflect the magnitude of end-organ damage were shown to be higher among patients with c-HELLP compared to p-HELLP [11]. A similar observation was made by Kaddour et al who found that although c-HELLP carried a significantly worse outcome, p-HELLP was associated with a high frequency of major morbid events, including 15% mortality [11].…”

Section: Discussionsupporting

confidence: 63%

“…Different clinical presenting features and laboratory values that reflect the magnitude of end-organ damage were shown to be higher among patients with c-HELLP compared to p-HELLP [11]. A similar observation was made by Kaddour et al who found that although c-HELLP carried a significantly worse outcome, p-HELLP was associated with a high frequency of major morbid events, including 15% mortality [11]. This view was contradicted by Abbade et al who suggested that aggressive procedures adopted for patients with p-HELLP resulting in immediate interruption of pregnancy, with elevated cesarean delivery rates and preterm delivery need to be reviewed [12].…”

Section: Discussionmentioning

confidence: 92%

“…Although there is universal agreement on a clear association between c-HELLP syndrome and maternal mortality, 1.1% as reported by Sibai et al [15], this can vary widely depending on the population studied, the diagnostic terms used and the presence of associated pre-existing medical conditions [16]. Maternal mortality rate ranged between 0.0 and 35.4% [5,10,11,17,18]. This variance in maternal mortality and other complications might reflect differences in prenatal care, hospital accessibility, inappropriate diagnostic and management protocols applied to these patients, such factors being more frequent in developing countries [16].…”

Section: Discussionmentioning

confidence: 96%

“…Maternal mortality is more prevalent in, but not limited to, patients with c-HELLP. Individual studies have reported 2.2%, 6.25% and 15.3% maternal mortality among patients with p-HELLP, which bears witness to the hazards that can complicate p-HELLP [11,17,18]. As in c-HELLP syndrome, all kinds of catastrophic morbidities can occur, including intracranial hemorrhage and liver hematoma, albeit at a lower frequency.…”

Section: Discussionmentioning

confidence: 99%

“…Kaddour et al reiterated this observation and indicated that although it is relevant to distinguish between partial and complete HELLP, mortality among patients admitted to an ICU was not seen with c-HELLP (40.0%) alone, but with complicated p-HELLP as well (15.0%). Mortality in p-HELLP was still very elevated, which argues for aggressive management as in c-HELLP [11].…”

Section: Discussionmentioning

confidence: 99%

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Appraisal of Short- and Long-Term Outcomes of Partial Versus Complete HELLP Syndromes: A Retrospective Cohort Study

Ramadan

Malas

El-Tal

et al. 2021

Journal of Fetal Medicine

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To compare short-term outcomes at index and subsequent pregnancies, as well as the long-term medical complications encountered later than 5 years after index pregnancy incomplete and partial HELLP syndromes. Pregnancies complicated by partial HELLP or complete HELLP during a period of 19 years were identified. Searches were limited to cases before 2012 to ensure an adequate follow-up period. Data on index or subsequent pregnancies occurring at our center were extracted from the hospital database, while data pertaining to subsequent obstetric outcomes when deliveries occurred elsewhere together with current medical conditions were acquired by patient self-reporting. Complete HELLP was defined as the presence of the 3 components of the syndrome whereas partial HELLP was defined by the presence of 1 or 2 components. 100 pregnancies were included. At index pregnancy, there was a higher rate of composite adverse maternal outcome in complete HELLP when compared to partial HELLP (45.8% vs 21.1%, p = 0.017). Outcomes at subsequent pregnancies showed no difference between the two variants of HELLP syndrome. When examined years later, a higher frequency of ''composite medical morbidity'' in the complete HELLP group was observed, though this difference did not reach statistical significance (77.7% vs 61.9%, p = 1.00). Although partial HELLP is relatively less harmful, it can nonetheless cause serious maternal complications including ruptured liver hematoma, intracranial hemorrhage and even mortality. These two clinical entities represent a continuum of the same pathology, which implies that the approach at management should be uniform. Furthermore, the prognosis and longterm outcomes were not different between these 2 variants.

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Section: Discussionsupporting

confidence: 63%