2P123 Effect of branched polyamine from hyperthermophile on the structure of genomic DNA(05B. Nucleic acid: Interaction & Complex formation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Abstract

Recently, the influence of radiation on human body has been recognized as a serious problem. In particular, highly-reactive radicals produced by the radiation react with DNA, resulting in damage on its structure and electronic properties. It is thus important to investigate the reaction mechanism of radicals to DNA for elucidating the initial damage in DNA induced by the radiation. In the present study, we search for the transition states of the attacking mechanism between base-pair (G-C or A-T) and radical (OH and H radicals) in vacuum and in water, using the density functional theory calculations. The results elucidate that OH radical can cause mutation in A-T base pair, while H radical affects significantly on G-C base pair. 2P122アルコールによって誘起される DNA の凝縮・脱凝縮二段階 転移 Condensed DNA is unfolded into elongated conformation at ethanol concentration around 80%