2P-0473 Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI)

Naruszewicz, Marek; Daniewski, M; Łaniewska, Iwona; Pikto-Pietkiewicz, Witold; Millo, Barbara; Zapolska-Downar, Danuta

doi:10.1016/s1567-5688(03)90615-5

Cited by 16 publications

(13 citation statements)

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“…The metabolic changes were associated with a reduction in systolic and diastolic blood pressure by a mean of 13 and 7 mm Hg, respectively [103]. A similar hypotensive effect of a flavonoid-rich extract from chokeberry fruits was lately observed in patients after myocardial infarction, treated simultaneously with statins and in patients with diabetes mellitus type II [104], [105], [106]. Other effects studied include enhanced reduction in cardiovascular risk markers in patients after myocardial infarction suggesting a possible clinical use for secondary prevention of isachaemic heart diesease [107].…”

Section: Cardioprotective Effectsmentioning

confidence: 93%

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

450

458

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Botanical Background and Cultivation ! Aronia berries originate from the eastern parts of North America and East Canada [1], [2], [3]. Their migration to Europe occurred around 1900 via Germany to Russia and back. Around 1946 the plant was established as a cultivar in the former Soviet Union. More recently it is cultivated also in East European countries and Germany (Oberlausitz) [1], [2]. The genus name Aronia has been replacing the common name, chokeberry. Two species can be distinguished: Aronia melanocarpa [Michx.] Elliot (black chokeberry, Aronia noir) and Aronia arbutifolia [L.] Elliot (red chokeberry, Aronia rouge) [3]. A third entity is intermediate and has variously been considered a species (A. prunifolia), a variety of each of the other two, or a hybrid [3]. The other common names for Aronia besides chokeberries include black apple berry and rowanberries (Sorbus aucuparia L.), whereby in the latter case the hybrids of rowanberry with Aronia are likely to be addressed [4], [5], [6]. Aronia is a member of the Rosaceae family, and the cultivars used for fruit production are from the species Aronia melanocarpa [6], [7], [8], [9]. Cultivars have been bred for larger edible fruits and ornamental value. The plants have no known pest problems [10]. Some cultivars are bred of true black chokeberry (Aronia melanocarpa) and some are hybrid cultivars (e. g., Aronia x Sorbus) [5], [11]. The more important cultivars include "Nero" (Czechia), "Rubina" (crossing from Russian and Finnish plants), "Viking" (Finland), "Kurkumäcki" (Finland), "Hugin" (Sweden), "Fertödi" (Hungary) and "Aron" (Denmark) [2]. "Viking" and "Nero" are cultivars that are commonly available in North American plant catalogues [7]. The Aronia shrubs can grow to a height of 2-3 m, which produce in May to June umbels of some 30 small white flowers, ripening to bright red (red chokeberry) or to purplish black berries (black chokeberry; Ø 6-13 mm, 0.5-2 g) [1], [2], [8], [12]. Harvest is performed mechanically between August and September. Five to twelve tons per hectare can be expected in about five years, once plants have matured [7], [8]. The effect of fertiliser rate on fruit quality parameters in the black chokeberry showed that an increased fertiliser application results in increased growth and higher yield whereas pigment content and total acidity decreased. Maximum production of anthocyanins per plant was obtained with a medium high fertiliser rate (50 kg N/ha, 44 kg P/ha, 100 kg K/ ha) [13]. The content of undesirable brown compounds and that of desirable anthocyanins is also dependent on maturation as documented in [11]. A recent study illustrates that applied fertilization may exert a differential influence on the chemical composition of Aronia fruits especially with regard to sugar content and the quantity

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Section: Cardioprotective Effectsmentioning

confidence: 93%

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

450

458

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“…Aronia extracts have been shown to positively impact CVD risk factors such as high blood pressure in patients after myocardial infarction (Naruszewicz et al . ) and metabolic syndrome (Chrubasik et al . ).…”

Section: Introductionmentioning

confidence: 99%

“…Aronia contains high levels of proanthocyanidins, flavanols, anthocyanins (cyanidin glycosides), flavonoids (quercetin glycosides), chlorogenic acids, caffeic acid, triterpenes and fibers (Bermudez-Soto et al 2007;Kokotkiewicz et al 2010). Aronia extracts have been shown to positively impact CVD risk factors such as high blood pressure in patients after myocardial infarction (Naruszewicz et al 2003) and metabolic syndrome (Chrubasik et al 2010). In an animal model of NG-nitro-L-arginine methyl ester induced hypertension via inhibition of eNOS, oral exposure to Aronia ethanolic extract for 8 weeks significantly reduced systolic and diastolic blood pressure (Ciocoiu et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of a Natural Extract ofAronia melanocarpaBerry on Endothelial Cell Nitric Oxide Production

Varela

Fromentin²,

Roller

et al. 2015

Journal of Food Biochemistry

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The effects of acute and chronic treatment with Aronia extracts on NO production and endothelial nitric oxide synthase (eNOS) phosphorylation in bovine coronary artery endothelial cells were investigated. Acute time-course and concentration-response experiments were performed to determine the time and concentration at which Aronia induced maximal NO synthesis and eNOS phosphorylation. The findings indicate that relatively low concentrations (0.1 μg/mL) of Aronia extract significantly induced NO synthesis and eNOS phosphorylation after 10 min of treatment. Increased sensitivity of eNOS and a significant increase in NO synthesis resulted from longer-term stimulation with Aronia (48 hr) and an acute re-treatment of the cells (10 min). PRACTICAL APPLICATIONS These in vitro results may be translated into potential future clinical applications where Aronia extracts may be used for prevention and coadjuvant treatment of cardiovascular diseases via increases in endothelial NO synthesis and related improvements in vascular functions. Given the dose-response effect of Aronia extract in vitro and metabolism of polyphenols that occurs in humans, dose-response studies would be necessary to define the optimal daily amount to be consumed.

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“…The available literature data provide strong evidence that products made from A. melanocarpa berries may constitute useful strategies for the prevention and treatment of noncommunicable diseases (Figure ). Well‐documented cases of health improvement as a result of the consumption of chokeberry products (mainly juices and extracts) in patients suffering from various diseases have been reported (Simeonov and others ; Naruszewicz and others , ; Kowalczyk and others ; Broncel and others , ; Skoczyńska and others ; Poręba and others ; Boncheva and others ; Kardum and others ). Moreover, there is also evidence which suggests the possible effectiveness of the leaves of this plant (Skupień and others ).…”

Section: Chokeberries and Their Products In The Prevention And Treatmmentioning

confidence: 97%

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

Borowska

Brzóska

2016

Comp Rev Food Sci Food Safe

102

155

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Aronia melanocarpa berries (chokeberries) constitute a very rich source of numerous substances exerting a beneficial impact on health, including mainly polyphenols (proanthocyanidins, anthocyanins, flavonoids, and phenolic acids), possessing antioxidative, anti-inflammatory, antiviral, anticancer, antiatherosclerotic, hypotensive, antiplatelet, and antidiabetic properties. Thus, the consumption of products made from chokeberries is of vital importance for health maintenance and protection. Nowadays, due to the growing prevalence of noncommunicable diseases and ubiquitous human exposure to numerous man-made and naturally occurring toxic substances, some of which are dangerous even at low amounts, it is very important to look for effective means of health protection. An important role in this regard may be played by A. melanocarpa berries; however, up to now the attention of scientists, nutritionists, and health practitioners has been focused mainly on the effectiveness of chokeberry products in the prevention and treatment of noncommunicable diseases, while only little attention has been paid to the possibility of their use to counteract the adverse health effects of exposure to xenobiotics. That is why in this review article the main interest has been focused on the possibility of using chokeberries in the protection against unfavorable health effects caused by the action of substances to which humans may be exposed environmentally and/or occupationally. The available experimental data indicate that not only the fruit but also the leaves of A. melanocarpa and their products may be effective means for prevention and treatment of the effects of toxic action of some xenobiotics in humans; however, further studies on this subject are necessary.

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2P-0473 Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI)

Cited by 16 publications

References 0 publications

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Effects of a Natural Extract ofAronia melanocarpaBerry on Endothelial Cell Nitric Oxide Production

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

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