2nd and 3rd Order Derivative Spectrophotometric Determination of Ascorbic Acid in Soft Drinks

Montelongo, F. García; Sánchez, M. Elena; Castro, J. C. García; Hardisson, Arturo

doi:10.1080/00032719108053019

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Different techniques were reported for the analysis of the studied drugs either simultaneously or for the determination of one drug in the presence of the other. These methods include derivative spectrophotometric [2][3][4][5][6][7][8][9][10][11] , colorimetric [12][13][14][15][16][17][18][19][20] , high performance liquid chromatography [21][22][23][24] and electrophoretic methods 25&26 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Paracetamol and Ascorbic Acid in Pharmaceutical Binary Mixture

Emara¹,

Abdel-Wadood²,

El-Koussi

et al. 2009

Bulletin of Pharmaceutical Sciences. Assiut

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Two simple and sensitive spectrophotometric methods were developed for the determination of paracetamol (I) and ascorbic acid (II) in pharmaceutical binary mixture. The first method depends on the use of the first-derivative spectrophotometric technique for the simultaneous determination of components of the mixture. The second method depends on the reaction of the studied drugs with 5-diazo-1, 2, 4-triazol-3-carboxylic acid (DTCA) reagent to give colored products measured at 480 nm and 380 nm for (I) and (II), respectively. All variables affecting reaction conditions were optimized. The proposed methods were successfully applied for the analysis of the studied drugs in their pure and commercial dosage forms and are in good agreement with those obtained from the reported methods. No significant difference in the accuracy and precision as revealed by the accepted values of t-and F-tests, respectively. Molar ratios of the drugs with the colorimetric reagent (DTCA) were determined and the reaction mechanisms were suggested.

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Section: Introductionmentioning

confidence: 99%

Analysis of Paracetamol and Ascorbic Acid in Pharmaceutical Binary Mixture

Emara¹,

Abdel-Wadood²,

El-Koussi

et al. 2009

Bulletin of Pharmaceutical Sciences. Assiut

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“…DS and BA possess partially overlapping spectra. One elegant approach to the problem of solving spectral overlap that has received attention in pharmaceutical analysis is offered by derivative spectroscopy [26]. Derivative methods have been successfully applied to the quantitative assay of drugs [26] and metals [27] in mixtures.…”

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confidence: 99%

Simultaneous spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceuticals using methods based on the first derivative of the optical density ratio

2005

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Two sensitive and accurate spectrophotometric methods are presented for simultaneous quantitative determination of benzyl alcohol and diclofenac in various pharmaceutical forms. The first method makes use of a derivative of the double-divisor-ratio spectrum of optical density. In this case, the linear determination ranges are 30 -97 mg/ml for benzyl alcohol and 12 -45 mg/ml for diclofenac. In the second method, the analytical signals are measured at wavelengths corresponding to either maxima or minima for both drugs in the spectra of the first derivative of the ratio of optical densities of the sample and the standard solution of one of the drugs. In this case, the linear determination ranges are 32 -95 mg/ml for benzyl alcohol and 14 -45 mg/ml for diclofenac. Both analytical procedures do not require any separation of the components. The proposed methods were satisfactorily applied to the rapid simultaneous determination of benzyl alcohol and diclofenac in commercial pharmaceutical preparations and semisynthetic pharmaceuticals containing these drugs.

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