2I1536 Water expelling pathway of cytochrome P450cam : Effect of mutation of a gate forming Asp297 to Leu on D-camphor binding(Heme proteins 2,The 48th Annual Meeting of the Biophysical Society of Japan)

Abstract

CyLochrome c oxidase (CcO) is the tenninal enzyme of the respiratory chaiii in mitochondria, which catalyzes the oxygen reduction at the hemc-eopper site, Ceupling mechanisrn between electron tTansfer and proten pumping reactions is to be elucidated. X-ray crystallography showed that herne a3 of the fi]11yreduced and