2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis

Thiele, Maja; Hugger, Mie Balle; Kim, Yongsoo; Rautou, Pierre‐Emmanuel; Elkrief, Laure; Jansen, Christian; Verlinden, Wim; Allegretti, Giulia; Israelsen, Mads; Ştefănescu, Horia; Piscaglia, Fabio; García‐Pagán, Juan Carlos; Franque, Sven; Berzigotti, Annalisa; Castéra, Laurent; Jeong, Woo Kyoung; Trebicka, Jonel; Krag, Aleksander

doi:10.1111/liv.14439

Cited by 41 publications

(28 citation statements)

References 28 publications

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“…Other technologies for LSM, pSWE and 2D-SWE, may perform similarly to TE, but only 1 centre has performed a head-to-head comparison between TE and 2D-SWE (Supersonic Aixplorer) 56 and only 2 recent studies have assessed pSWE using the Virtual Touch technique (Siemens Acuson 2000), with no comparator. 57,58 It has been debated whether active use of alcohol may cause false positive LSMs.…”

Section: Alcohol-related Liver Diseasementioning

confidence: 99%

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

Berzigotti¹,

Tsochatzis²,

Boursier³

et al. 2021

Journal of Hepatology

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791

615

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Section: Alcohol-related Liver Diseasementioning

confidence: 99%

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

Berzigotti¹,

Tsochatzis²,

Boursier³

et al. 2021

Journal of Hepatology

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791

615

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“…The technical advances have nowadays elastography in any ultrasound machine and is routine in the exploration of the liver and also other organs. The best validated for portal hypertension is Fibroscan, which is recommended by Baveno to guide screening endoscopy for varices, followed by 2D-Shear-wave elastography of Aixplorer, the last being superior in patients with ascites (42,(138)(139)(140). The combination of liver and spleen stiffness measurement seems to be the most accurate to assess CSPH and the effect of portal pressure lowering strategies (42,125,139).…”

Section: Non-invasive Toolsmentioning

confidence: 99%

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Iwakiri

Trebicka

2021

JHEP Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…As for the advanced technology, share wave elastography (possible evaluation of liver/spleen stiffness with realtime observation even in patients with ascites), which is available for noninvasive prediction of the severity of portal hypertension and EV (87)(88)(89). However, it is an indirect assessment and lower specificity may be the disadvantage.…”

Section: Summary Of Imaging Techniques For the Evaluation Of Portal System And Collateralsmentioning

confidence: 99%

Collaterals in portal hypertension: anatomy and clinical relevance

Maruyama¹,

Shiina²

2021

Quant Imaging Med Surg

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Portal hypertension is a key pathophysiology of chronic liver diseases typified with cirrhosis or noncirrhotic portal hypertension. The development of collateral vessels is a characteristic feature of impaired portal hemodynamics. The paraumbilical vein (PUV), left gastric vein (LGV), posterior gastric vein (PGV), short gastric vein (SGV), splenorenal shunt (SRS), and inferior mesenteric vein (IMV) are major collaterals, and there are some rare collaterals. The degree and hemodynamics of collateral may affect the portal venous circulation and may compensate for the balance between inflow and outflow volume of the liver. Additionally, the development of collateral shows a relation with the liver function reserve and clinical manifestations such as esophageal varices (EV), gastric varices, rectal varices and the other ectopic varices, hepatic encephalopathy, and prognosis. Furthermore, there may be an interrelationship in the development between different collaterals, showing additional influences on the clinical presentations. Thus, the assessment of collaterals may enhance the understanding of the underlying pathophysiology of the condition of patients with portal hypertension. This review article concluded that each collateral has a specific function depending on the anatomy and hemodynamics and is linked with the relative clinical presentation in patients with portal hypertension. Imaging modalities may be essential for the detection, grading and evaluation of the role of collaterals and may help to understand the pathophysiology of the patient condition. Further investigation in a large-scale study would elucidate the basic and clinical significance of collaterals in patients with portal hypertension and may provide information on how to manage them to improve the prognosis as well as quality of life.

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2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis

Cited by 41 publications

References 28 publications

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Collaterals in portal hypertension: anatomy and clinical relevance

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