2D-Shear Wave Elastography in the Evaluation of Parathyroid Lesions in Patients with Hyperparathyroidism

Golu, Ioana; Sporea, Ioan; Moleriu, Lavinia Cristina; Tudor, Anca; Cornianu, Mărioara; Vlad, Adrian; Timar, Romulus; Balaş, Melania; Amzar, Daniela; Vlad, Mihaela

doi:10.1155/2017/9092120

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…Also, the region-of-interest field dimensions are not fixed as in most of the ARFI devices (0.5 × 0.6 cm) and can be changed accordingly to the size of the analyzed lesion. The only study performed with the use of the same method and device (Supersonic Imagine Aixplorer system), on significantly smaller group of patients ( n = 22), revealed similar results to our study–significantly higher parathyroid elasticity than surrounding thyroid tissue [ 28 ], but the authors did not include thyroid lesions in the assessment.…”

Section: Discussionsupporting

confidence: 83%

Shear wave elastography in the diagnostics of parathyroid adenomas–new application of the method

2018

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Purpose:Shear wave elastography (SWE) was described as valuable tool in the diagnostics of distinct types of thyroid lesions, thyroiditis and several other non-thyroidal conditions, such as liver inflammation and fibrosis or diagnostics of breast lesions. The aim of the current study was to assess the appearance of parathyroid adenomas in SWE and to check prospectively if SWE can be valuable additional tool in the diagnostics of pathologically enlarged parathyroids.Methods:Patients with parathyroid adenomas confirmed by histopathology were included. Subjects with benign thyroid lesions were enrolled to the control group. Elasticity of parathyroid adenomas and benign thyroid nodules was measured and compared.Results:Sixty five patients with parathyroid adenomas and 35 patients with 51 benign thyroid nodules were included. Parathyroid adenomas where significantly more elastic than benign thyroid nodules–mean elasticity of the lesion was 5.2 ± 7.2 vs. 24.3 ± 33.8 kPa, respectively. Relative mean elasticity (in comparison with surrounding thyroid tissue) was 0.30 ± 0.36 and 2.8 ± 3.9, respectively.Conclusions:SWE can be useful tool in the diagnostics of parathyroid adenomas. Enlarged parathyroids are significantly more elastic than benign thyroid lesions. Low elasticity of the lesion constitutes feature with high negative prognostic value, allowing for reliable exclusion of suspicion of parathyroid adenomas.

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Section: Discussionsupporting

confidence: 83%

Shear wave elastography in the diagnostics of parathyroid adenomas–new application of the method

2018

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“…Application of SWE with Virtual Touch tissue imaging quantification (VTIQ) enabled the differentiation between parathyroid adenoma and hyperplasia, as well as cervical lymph nodes [124]. Golu et al suggested that the cutoff value for SWE-Mean should be set at 12.5 kPa to provide an accurate diagnosis of parathyroid adenoma [70]. According to researchers, subjects with SWE-Mean value lower than 12.5 kPa present a high probability of parathyroid adenoma presence.…”

Section: Shear Wave Elastographymentioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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Accurate pre-operative determination of parathyroid glands localization is critical in the selection of minimally invasive parathyroidectomy as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Its importance cannot be overemphasized as it helps to minimize the harmful side effects associated with damage to the parathyroid glands such as in hypocalcemia, severe hemorrhage or recurrent laryngeal nerve dysfunction. Preoperative and intraoperative methods decrease the incidence of mistakenly injuring the parathyroid glands and allow for the timely diagnosis of various abnormalities, including parathyroid adenomas. This article reviews 139 studies conducted between 1970 and 2020 (49 years). Studies that were reviewed focused on several techniques including application of carbon nanoparticles, carbon nanoparticles with technetium sestamibi (99m Tc-MIBI), Raman spectroscopy, near-infrared autofluorescence, dynamic optical contrast imaging, laser speckle contrast imaging, shear wave elastography, and indocyanine green to test their potential in providing proper parathyroid glands’ localization. Apart from reviewing the aforementioned techniques, this study focused on the applications that helped in the detection of parathyroid adenomas. Results suggest that applying all the reviewed techniques significantly improves the possibility of providing proper localization of parathyroid glands, and the application of indocyanine green has proven to be the ‘ideal’ approach for the diagnosis of parathyroid adenomas.

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“…Parathyroid lesions also need to be differentiated from other neck lesions, such as thyroid nodules and lymph nodes (14). After evaluating 2D shear wave USE features of pathologically confirmed PAs, Golu et al .…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasound elastography (USE) is a non-invasive and dynamic technique that objectively evaluates tissue hardness by measuring tissue elasticity (14, 15, 16). The principle for USE is based on the higher likelihood of softer tissues to deform under compression by an external force compared with harder tissues (17).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound elastography score and strain index in different parathyroid lesions

Çakır

Seyrek

Topaloğlu

et al. 2019

Endocrine Connections

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BackgroundDespite significant improvement in imaging quality and advanced scientific knowledge, it may still sometimes be difficult to distinguish different parathyroid lesions. The aims of this prospective study were to evaluate parathyroid lesions with ultrasound elastography and to determine whether strain index can help to differentiate parathyroid lesions.MethodsPatients with biochemically confirmed hyperparathyroidism and localised parathyroid lesions in ultrasonography were included. All patients underwent B-mode US and USE examination. Ultrasound elastography scores and strain index of lesions were determined. Strain index was defined as the ratio of strain of the thyroid parenchyma to the strain of the parathyroid lesion.ResultsData of 245 lesions of 230 patients were analysed. Histopathologically, there were 202 (82.45%) parathyroid adenomas, 26 (10.61%) atypical parathyroid adenomas, and 17 (6.94%) cases of parathyroid hyperplasia. Median serum Ca was significantly higher in atypical parathyroid adenoma patients than parathyroid hyperplasia patients (P = 0.019) and median PTH was significantly higher in APA compared to PA patients (P < 0.001). In 221 (90.2%) of the parathyroid lesions, USE score was 1 or 2. The median SI of atypical parathyroid adenomas was significantly higher than parathyroid adenomas and hyperplasia lesions (1.5 (0.56–4.86), 1.01 (0.21–8.43) and 0.91 (0.26–2.02), respectively, P = 0.003).ConclusionOur study revealed that SI of parathyroid lesions as well as serum calcium, parathyroid hormone levels, and B-mode US features may help to predict the atypical parathyroid adenoma. Ultrasound elastography can be used to differentiate among parathyroid lesions and guide a surgical approach.

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2D-Shear Wave Elastography in the Evaluation of Parathyroid Lesions in Patients with Hyperparathyroidism

Cited by 8 publications

References 30 publications

Shear wave elastography in the diagnostics of parathyroid adenomas–new application of the method

Shear wave elastography in the diagnostics of parathyroid adenomas–new application of the method

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

Ultrasound elastography score and strain index in different parathyroid lesions

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