2D Nanozymes Modulate Gut Microbiota and T‐Cell Differentiation for Inflammatory Bowel Disease Management

Abstract

Intestinal commensal microbiota dysbiosis and immune dysfunction are significant exacerbating factors in inflammatory bowel disease (IBD). To address these problems, we developed Pluronic F‐127‐coated tungsten diselenide (WSe2@F127) nanozymes by simple liquid‐phase exfoliation. The abundant valence transitions of elemental selenium (Se2−/Se4+) and tungsten (W4+/W6+) enable the obtained WSe2@F127 nanozymes to eliminate reactive oxygen/nitrogen species (RONS). In addition, the released tungsten ions were capable of inhibiting the proliferation of Escherichia coli. In a model of DSS‐induced colitis, WSe2@F127 nanozymes modulated the gut microbiota by increasing the abundance of bacteria S24‐7 and significantly reducing the abundance of Enterobacteriaceae. Moreover, WSe2@F127 nanozymes inhibited T‐cell differentiation and improved intestinal immune barrier function in a model of Crohn's disease. The WSe2@F127 nanozymes effectively alleviate IBD by reducing oxidative stress damage, modulating intestinal microbial populations, and remodeling the immune barrier.This article is protected by copyright. All rights reserved