Diagnostic Accuracy of Real-Time Sonography in Differentiating Diffuse Thyroid Disease From Normal Thyroid Parenchyma: A Multicenter Study

Ahn, Hye Shin; Kim, Do Hun; Lee, Yoo Jin; Baek, Hye Jin; Ryu, Ji Hwa

doi:10.2214/ajr.17.19164

Cited by 15 publications

(19 citation statements)

References 18 publications

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“…One study reported that there was no significant difference between readers’ experience and diagnostic accuracy [ 9 ]. In contrast, another study stated that diagnostic accuracy increased with experience of the radiologist [ 11 ]. In our study, no significant association was found between the readers’ experience and diagnostic accuracy.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of computed tomography for differentiating diffuse thyroid disease from normal thyroid parenchyma: A multicenter study

et al. 2018

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This study aimed to assess the diagnostic performance of computed tomography (CT) for differentiating diffuse thyroid disease (DTD) from normal thyroid parenchyma (NTP) using multicenter data. Between January 2016 and June 2016, 229 patients underwent preoperative neck CT and subsequent thyroid surgery at five participating institutions. The neck CT images of each patient were retrospectively reviewed and classified into the following four categories: no DTD, indeterminate, suspicious for DTD, and DTD. The results of the CT image evaluations were compared with the histopathological results to determine the diagnostic accuracy of CT at each institution. According to the histopathological results, there were NTP (n = 151), Hashimoto thyroiditis (n = 24), non-Hashimoto lymphocytic thyroiditis (n = 47), and diffuse hyperplasia (n = 7). The CT categories of the 229 patients were “no DTD” in 89 patients, “indeterminate” in 40 patients, “suspicious for DTD” in 42 patients, and “DTD” in 58 patients. The presence of two or more CT features of DTD, which was classified as “suspicious for DTD” by all radiologists, had the largest area under the receiver-operating characteristic curve (Az = 0.820; 95% confidence interval: 0.764, 0.868), with sensitivity of 85.9% and specificity of 78.2%. However, no statistical significance between readers’ experience and their diagnostic accuracy was found. In conclusion, evaluations of CT images are helpful for differentiating DTD from NTP.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of computed tomography for differentiating diffuse thyroid disease from normal thyroid parenchyma: A multicenter study

et al. 2018

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“…Doppler US of the thyroid gland is helpful for the early detection of incidental asymptomatic DTD [69,[77][78][79] and the differential diagnosis of GD with destructive thyroiditis in thyrotoxicosis [73][74][75][76][80][81][82][83][84][85][86]. It can also provide valuable information on the functional status of the thyroid and can be used to evaluate disease remission, recurrence, and response to treatment [68,73,81,84,87].…”

Section: Diagnosis Of Diffuse Parenchymal Disease Of the Thyroid Glandmentioning

confidence: 99%

“…In addition, Doppler US can be used to evaluate disease remission, recurrence, and response to treatment in DTD. However, it is dependent on a skilled operator [74,77,79]. Doppler US should be performed using sensitive equipment by a trained operator with good reproducibility [74,77,79].…”

Section: Summary Consensus and Limitationsmentioning

confidence: 99%

“…Thyroid US can be helpful in differentiating asymptomatic DTD from normal thyroid parenchyma [ 69 , 77 - 79 ]. A recent multicenter study found significant differences in US features of the thyroid gland between patients with normal thyroid parenchyma (n=139) and those with asymptomatic DTD (n=64; HT, non-HT, and diffuse hyperplasia; P<0.001); these differences included parenchymal echogenicity, parenchymal echotexture, AP diameter of the thyroid gland, glandular margin, and parenchymal vascularity.…”

Section: Clinical Applications Of Doppler Usmentioning

confidence: 99%

“…However, it is dependent on a skilled operator [ 74 , 77 , 79 ]. Doppler US should be performed using sensitive equipment by a trained operator with good reproducibility [ 74 , 77 , 79 ]. It is important to use the proper technique with the appropriate transducer and equipment adjustments [ 74 - 77 , 79 , 83 , 86 ].…”

Section: Clinical Applications Of Doppler Usmentioning

confidence: 99%

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Clinical applications of Doppler ultrasonography for thyroid disease: consensus statement by the Korean Society of Thyroid Radiology

et al. 2020

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Doppler ultrasonography (US) is widely used for the differential diagnosis of thyroid nodules, metastatic cervical lymph nodes in patients with thyroid cancer, and diffuse parenchymal disease, as well as for guidance in various US-guided procedures, including biopsy and ablation. However, controversies remain regarding the appropriate use and interpretation of Doppler US. Therefore, the Korean Society of Thyroid Radiology organized a taskforce to develop a consensus statement on the clinical use of Doppler US for thyroid disease. The review and recommendations in this article are based on a comprehensive analysis of the current literature and the consensus of experts.

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Malignancy risk of indeterminate lymph node at the central compartment in patients with thyroid cancer and concomitant sonographic thyroiditis

Rhim,

Lee,

Park

et al. 2024

Head & Neck

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BackgroundTo evaluate the malignancy risk of sonographic (US) indeterminate lymph node (LN)s at the central compartment in thyroid cancer patients with US‐thyroiditis (ST).MethodsAmong the central compartments of suspicious, indeterminate, and probably benign LN US categories, the malignancy rates were compared between ST and non‐US‐thyroiditis (non‐ST) groups. Those of indeterminate category were compared with suspicious and probably benign categories.ResultsAt 531 central compartments from 349 patients, the malignancy rate was lower in ST group (34.4% [44/128]) than non‐ST group (43.4% [175/403]), although statistically not significant (p = 0.08). The malignancy rate of indeterminate category in ST group (35.7% [5/14]) was lower than non‐ST group (71.9% [23/32]) (p = 0.047). Within ST group, the malignancy rate of indeterminate category (35.7% [5/14]) did not differ from probably benign category (29.1% [30/103]) (p = 0.756), but was lower than suspicious category (81.8% [9/11]) (p = 0.042).ConclusionsThe malignancy risk of US indeterminate LNs at the central compartment in thyroid cancer patients with US thyroiditis was lower than that in patients without US thyroiditis.

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Diagnostic Accuracy of Real-Time Sonography in Differentiating Diffuse Thyroid Disease From Normal Thyroid Parenchyma: A Multicenter Study

Abstract: Real-time US can be helpful for differentiating DTD from normal thyroid parenchyma.

Cited by 15 publications

References 18 publications

Diagnostic accuracy of computed tomography for differentiating diffuse thyroid disease from normal thyroid parenchyma: A multicenter study

Diagnostic accuracy of computed tomography for differentiating diffuse thyroid disease from normal thyroid parenchyma: A multicenter study

Clinical applications of Doppler ultrasonography for thyroid disease: consensus statement by the Korean Society of Thyroid Radiology

Malignancy risk of indeterminate lymph node at the central compartment in patients with thyroid cancer and concomitant sonographic thyroiditis

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