Recent development of chromatographic methods to determine parabens in breast milk samples: A review

Grecco, Caroline Fernandes; Souza, Israel Donizéti de; Queiroz, Maria Eugênia Costa

doi:10.1016/j.jchromb.2018.06.059

Cited by 21 publications

(9 citation statements)

References 52 publications

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“…Liquid–liquid extraction and solid-phase extraction have often been used for this purpose. LLE requires the use of a large amount of sample, which in the case of breast milk, is not demanded, whereas in solid-phase extraction, traditional sorbents often do not allow complete purification of the extract, and the use of reagents is much higher than in dispersive solid-phase extraction [ 19 , 21 , 44 , 45 ]. In connection with the above, the use of a new sorbent, such as MMIP, with a selective cavity allows obtaining specific interactions, better cleaning of the sample (minimizing the matrix effect), and the possibility of skipping time-consuming centrifuging and filtration.…”

Section: Resultsmentioning

confidence: 99%

“…Since parabens are still commonly used as preservatives, and considering their long-term side-effects, there is a need to monitor these compounds in the environment and, in particular, in biological samples, one of which can be human milk. Because breastfeeding is the main source of nutrition for infants, and during this period, children are particularly vulnerable, lactating women can expose children to hazardous paraben levels [ 19 ]. There have already been studies focusing on this issue reporting the use of different methods of sample preparation for human milk with traditional solvents and sorbents, such as liquid–liquid extraction (LLE) [ 20 ], solid-phase extraction (SPE) [ 21 ], ultrasound-assisted extraction (UAE) [ 22 ], dispersive liquid–liquid microextraction (DLLME) [ 23 ] as well as quick easy cheap effective rugged safe (QuEChERS) technique [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r2 from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL−1; LOQ from 3.6–8.1 ng mL−1), which makes their quantitative analysis in real samples feasible.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

et al. 2020

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“…31 Ayrıca, kişisel bakım ürünlerinde yer alan parabenlerin anne sütüne geçebileceği, özellikle göğüs bölgesi için kullanılan ürünler ile de bu oranların artış göstermiş olabileceği vurgulanmaktadır. 32…”

Section: Kozmeti̇k üRünler İle Maruz Kalinabi̇len Endokri̇n Bozucu Ki̇myaunclassified

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

Karaman¹,

Özden²

2019

J Lit Pharm Sci

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“…There are different analytical methods available to investigate the presence of parabens and their derivatives. Some of the techniques include Solid phase extraction method, high performance liquid chromatographic techniques (HPLC), gas chromatographic techniques (GC), spectrophotometry and capillary electrophoresis . Though these techniques are available in laboratory practices, they are expensive, extensive sample preparation procedures involved, time‐consuming and trained personnel required to operate the equipment .…”

Section: Introductionmentioning

confidence: 99%

Tailoring the electrochemical interface of mesoporous carbon with ubiquinone for detection of parabens in cosmetics

et al. 2020

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Quality assessment of paraben in cosmetic products is in need to avoid and control the deadly side effect caused in humans. Though, there are various studies reported on sensing paraben electrochemically, the use of chemical modifiers is restricted to carbon based materials due to its efficiency but, the mesoporous carbon with high surface area and electron transfer property is hitherto unexplored. Here, we have investigated the sensing of paraben and its derivatives by using ubiquinone (Q10) introduced mesoporous carbon (MPC) via cyclic voltam-metric (CV) and differential pulse voltammetric (DPV) techniques. The morphological studies of MPC showed rod shaped structure. The pore size and the pore volume were found to be 3.93 nm and 0.4 cm 3 /g respectively. The fabricated sensor showed good electrocatalytic activity for detecting methyl, ethyl and propyl paraben with the detection limit of 0.26 μM, 0.3 μM and 1.07 μM, respectively. Real time measurements of the modification were further utilized for commercially available cosmetic samples. MP : 0.271 μA/μM EP : 0.216 μA/ μM PP : 0.067 μA/μM Present Work GCE = Glassy carbon electrode, Q10 = Coenzyme Ubiquinone, MWCNT = Multiwalled Carbon nanotubes, MP = Methyl paraben, EP = Ethyl paraben, PP = Propyl Paraben, CPE = Carbon paste electrode, LoD = Lower detection limit, GO = Graphene oxide. ChemistrySelectFull Papers

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Recent development of chromatographic methods to determine parabens in breast milk samples: A review

Cited by 21 publications

References 52 publications

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

Tailoring the electrochemical interface of mesoporous carbon with ubiquinone for detection of parabens in cosmetics

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