Bacteriotherapy for preventing recurrent upper respiratory infections in children: a real-world experience

Abstract

Background Recurrent upper respiratory infections (RURI) constitute a social problem for both their pharmaco-economic impact and the burden for the family. Bacteriotherapy could be an interesting preventive option. Objective The aim of this study was to evaluate the preventive effects of RURI in children. Design The study was designed as spontaneous, and was conducted in real-life seting. Globally, 80 children (40 males, mean age 5.26 (2.52) years) with RURI were enrolled. Children were treated with Streptococcus salivarius 24SMB and Streptococcus oralis 89a: nasal spray 2 puffs per nostril twice/day for a week for 3 monthly courses. Number of URI, and school and work absences were evaluated and compared with the past year. Results Bacteriotherapy significantly halved the mean number of URI episodes being 5.98 (2.30) in the past year and 2.75 (2.43) after the treatment (p<0.0001). Bacteriotherapy also induced an over 35% reduction both in the number of school days and in the number of working days missed per month from 4.50 (2.81) to 2.80 (3.42) and from 2.33 (2.36) to 1.48 (2.16) respectively (p<0.0001). Conclusions This and real-life study provides the first evidence that Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray could be effective in preventing RURI in children.

Bacterial salivary microbiome associates with asthma among african american children and young adults

“…The fact that Streptococcus was found to be more prevalent in healthy controls in this study could be explained by a higher abundance of commensal species among nonasthmatic individuals, such as Streptococcus salivarius and Streptococcus oralis , which would maintain the stability of the community against pathogenic species. In fact, previous studies have shown that the administration of certain strains of both species via nasal spray reduced the occurrence of upper respiratory tract infections, significantly diminishing the occurrence of the episodes, as well as the number of school and work absences . Therefore, our results suggest that future studies are needed to understand whether topical administration of probiotics may effectively change the oral or lung microbiome and, consequently, become a new strategy in asthma management and/or prevention.…”

“…In fact, previous studies have shown that the administration of certain strains of both species via nasal spray reduced the occurrence of upper respiratory tract infections, 33,34 significantly diminishing the occurrence of the episodes, as well as the number of school and work absences. 35 Therefore, our results suggest that future studies are needed to understand whether topical administration of probiotics may effectively change the oral or lung microbiome and, consequently, become a new strategy in asthma management and/or prevention. In contrast to the results obtained for Streptococcus, the genus Veillonella was found to be associated with higher risk for asthma, which is consistent with the differences observed in a previous study in the gut microbiome composition, focused on children at 1-year old that later developed asthma at the age of 5 years.…”

Prevention of recurrent respiratory infections

“…Nasal administration of a mixture containing Streptococcus salivarius 24SMB and Streptococcus oralis 89a was correlated with a reduction in the number of RRIs compared to the previous year (2.75 vs 5.98 episodes/year, p = 0.0001), the number of school days (2.80 vs 4.50 days/month, p = 0.0001) and workdays lost (1.48 vs 2.33 days/month, p = 0.0001) [ 34 ].…”

Non-drug technologies in the complex therapy of chronic adenoiditis

“…Такой подход повышает трансформацию полученной энергии к поврежденным тканям. Это объясняет отдельные моменты пусковых звеньев биофизических, физико-химических и биологических процессов, связанных с возбуждением или нагреванием тканей, определяющих специфичность их лечебных эффектов [50,51].…”