Hyperbaric Oxygen Protects Against Cerebral Damage in Permanent Middle Cerebral Artery Occlusion Rats and Inhibits Autophagy Activity

Lu, Kongmiao; Wang, Hairong; Ge, Xiaoli; Liu, Qinghua; Chen, Miao; Shen, Yong; Li, Xuan; Pan, Shuming

doi:10.1007/s12028-018-0577-x

Cited by 12 publications

(7 citation statements)

References 34 publications

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“…Hyperbaric oxygen (HBO) suppresses autophagy activity and inhibits apoptosis and necrosis levels, thereby conferring neuroprotection against ischemic brain injury [99].…”

Section: The Autophagy-lysosome Pathway Inhibition and Thementioning

confidence: 99%

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

Chen

Qin

Tan

et al. 2020

Oxidative Medicine and Cellular Longevity

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The ubiquitin-proteasome pathway and autophagy-lysosome pathway are two major routes for clearance of aberrant cellular components to maintain protein homeostasis and normal cellular functions. Accumulating evidence shows that these two pathways are impaired during cerebral ischemia, which contributes to ischemic-induced neuronal necrosis and apoptosis. This review aims to critically discuss current knowledge and controversies on these two pathways in response to cerebral ischemic stress. We also discuss molecular mechanisms underlying the impairments of these protein degradation pathways and how such impairments lead to neuronal damage after cerebral ischemia. Further, we review the recent advance on the understanding of the involvement of these two pathways in the pathological process during many therapeutic approaches against cerebral ischemia. Despite recent advances, the exact role and molecular mechanisms of these two pathways following cerebral ischemia are complex and not completely understood, of which better understanding will provide avenues to develop novel therapeutic strategies for ischemic stroke.

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“…Hyperbaric oxygen (HBO) suppresses autophagy activity and inhibits apoptosis and necrosis levels, thereby conferring neuroprotection against ischemic brain injury [99].…”

Section: The Autophagy-lysosome Pathway Inhibition and Thementioning

confidence: 99%

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

Chen

Qin

Tan

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…HBOT preconditioning may reduce edema via downregulation of aquaporin 4 (AQP-4) expression, which possess the mechanism to hinder hemorrhage and preserve neural tissue [ 131 ]. Cultured astrocytes post-HBOT revealed an increase in AQP-4 and VEGF, demonstrating the ability to modulate BBB openings.…”

Section: Pre-clinical Findings With Hbot Preconditioning For Strokmentioning

confidence: 99%

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

et al. 2020

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Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.

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“…Therefore, this anti-inflammatory cytokine (IL-10) plays a crucial role in mediating the neuroprotective effect of HBO. The immediate inhalation of HBO (2.0 atmosphere absolute (ATA), 1 ATA = 1.013 kPa, 100% O 2 ) after brain injury decreases apoptosis25 and reduces the expression of inflammatory cytokines 232426. Moreover, HBO has been found to protect the integrity of the blood-brain barrier (BBB) and improve the patient prognosis 2469.…”

Section: Hyperbaric Oxygenmentioning

confidence: 99%

Recent advances in the neuroprotective effects of medical gases

Wang¹,

Li²,

Cao³

et al. 2019

Med Gas Res

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Central nervous system injuries are a leading cause of death and disability worldwide. Although the exact pathophysiological mechanisms of various brain injuries vary, central nervous system injuries often result in an inflammatory response, and subsequently lead to brain damage. This suggests that neuroprotection may be necessany in the treatment of multiple disease models. The use of medical gases as neuroprotective agents has gained great attention in the medical field. Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon. The neuroprotection from these medical gases has been investigated in experimental animal models of various types of brain injuries, such as traumatic brain injury, stroke, subarachnoid hemorrhage, cerebral ischemic/reperfusion injury, and neurodegenerative diseases. Nevertheless, the transition into the clinical practice is still lagging. This delay could be attributed to the contradictory paradigms and the conflicting results that have been obtained from experimental models, as well as the presence of inconsistent reports regarding their safety. In this review, we summarize the potential mechanisms underlying the neuroprotective effects of medical gases and discuss possible candidates that could improve the outcomes of brain injury.

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Hyperbaric Oxygen Protects Against Cerebral Damage in Permanent Middle Cerebral Artery Occlusion Rats and Inhibits Autophagy Activity

Cited by 12 publications

References 34 publications

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

Recent advances in the neuroprotective effects of medical gases

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