Towards rubella elimination in Japan

Jindai, Kazuaki; Funaki, Takanori; Nishijima, Takeshi; Takakura, Shunji; Noda, Hiroyuki; Miyake, Kuniaki

doi:10.1016/s1473-3099(18)30356-6

Cited by 20 publications

(12 citation statements)

References 2 publications

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“…Rubella is a contagious, mild viral infection that occurs mostly in children, leading to a vaccine-preventable disease through respiratory droplet [1,2]. During 2012-2013, Japan had a large rubella outbreak with more than 16000 cases, including 45 cases of congenital rubella syndrome [3]. The Ministry of Health, Labor, and Welfare in Japan issued the Guidelines for the Prevention of Specific Infectious Diseases: Rubella in 2014, and promoted preventive measures throughout the country [4].…”

Section: Introductionmentioning

confidence: 99%

Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019

et al. 2020

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Background Rubella virus infection mainly causes illness with mild fever, rash, and lymphadenopathy in children; however, the clinical characteristics of adult rubella are not well-known. Methods An observational study was conducted to compare the characteristics between adult rubella and adult non-rubella among participants aged �18 years, with suspected symptomatic rubella. Participants were screened for rubella-specific IgM expression using an enzyme immune assay kit, at a tertiary care hospital in

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Section: Introductionmentioning

confidence: 99%

Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019

et al. 2020

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“…The government of Japan aimed to verify the elimination of rubella by 2020, when, before the outbreak of coronavirus disease 2019 (COVID-19), the country was planning to host the Summer Olympic Games (Jindai et al, 2018); ironically, however, without good herd immunity, repeated introductions can cause continued transmission, and welcoming in more visitors increases the risk of an outbreak (Nishiura et al, 2019).…”

Section: Figures Andmentioning

confidence: 99%

“…Therefore, Japan is repeating experiments to test herd immunity using various vaccine-preventable imported diseases (e.g., measles), which have mostly resulted in a sporadic or small number of secondary transmissions, but sometimes resulting in a large cluster of cases ( Nishiura et al, 2016 , Shimizu et al, 2018 ). The government of Japan aimed to verify the elimination of rubella by 2020, when, before the outbreak of coronavirus disease 2019 (COVID-19), the country was planning to host the Summer Olympic Games ( Jindai et al, 2018 ); ironically, however, without good herd immunity, repeated introductions can cause continued transmission, and welcoming in more visitors increases the risk of an outbreak ( Nishiura et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Identifying geographic areas at risk of rubella epidemics in Japan using seroepidemiological data

Kayano

Lee

Kinoshita

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Recently, the Japanese government decided to implement a unique rubella immunization program in response to the rubella outbreak in 2018-2019, targeting susceptible men born from scal years 1962 to 1978, who did not have the opportunity to be vaccinated against rubella as children [8,9]. Under the new program, free vaccination is provided for participants with negative rubella antibody test results (i.e., < 8 IU/ml using the hemagglutination inhibition method) [5].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Participation in an Ongoing National Catch-up Campaign Against Rubella: A Cross-sectional Internet Survey Among 1,680 Adult Men in Japan

Hori

YOSHII

Isaka

et al. 2020

Preprint

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BackgroundSince 2019, aiming to eliminate periodic rubella outbreaks, the Japanese government has provided a rubella immunization program targeting men born in fiscal years 1972 to 1978, who lacked the opportunity to be vaccinated against rubella in childhood. This study aimed to explore the factors associated with participation in the rubella vaccination program among the first-year target population in 2019.MethodsA total of 11,754 adult men in Japan born in fiscal years 1972 to1978 living in seven rubella epidemic areas (Tokyo, Chiba, Kanagawa, Saitama, Aichi, Osaka, and Fukuoka) were selected from a list of a survey agency and invited to complete an Internet questionnaire in March 2020. Recruitment ended when the participants reached 1,680 individuals. Multivariable log binomial regression analyses were performed to explore the association between awareness of rubella prevention and rubella antibody testing in fiscal year 2019, adjusting for social characteristics.ResultsOf the 1,680 men aged 41–47 years who completed the survey, approximately half (51.3%) said that they had received a voucher for the rubella antibody testing and vaccination program. One-quarter (25.9%) of the respondents had used the voucher for rubella antibody testing in 2019, and 6.0% had used the voucher for rubella vaccination in fiscal year 2019. Respondents who understood the government recommendation for rubella antibody testing and vaccination for men of their generation (odds ratio [OR]: 5.50; 95% confidence interval [CI]: 4.01–7.53), those with acquaintances who had undergone rubella testing (OR: 1.39; 95% CI: 1.22–1.59), and those who knew that about their lack of opportunity for rubella vaccination (OR: 1.33; 95% CI: 1.11–1.60) tended to undergo rubella antibody testing. Receiving the most recent seasonal influenza vaccination (OR: 1.26; 95% CI: 1.10–1.43) and being able to confirm a rubella vaccination history (OR: 1.28; 95% CI: 1.13–1.46) were also associated with rubella antibody testing.ConclusionsThe ongoing Japanese test-and-vaccinate rubella program has yet to achieve its participation rate goal for 2019. Further dissemination of the government recommendation to the population is necessary, along with improvements in the accessibility of the rubella vaccination program.

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Towards rubella elimination in Japan

Cited by 20 publications

References 2 publications

Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019

Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019

Identifying geographic areas at risk of rubella epidemics in Japan using seroepidemiological data

Factors Associated With Participation in an Ongoing National Catch-up Campaign Against Rubella: A Cross-sectional Internet Survey Among 1,680 Adult Men in Japan

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