A new device-aided cognitive function test, User eXperience-Trail Making Test (UX-TMT), sensitively detects neuropsychological performance in patients with dementia and Parkinson’s disease

Kokubo, Naomi; Yokoi, Yuma; Saitoh, Yuji; Murata, Miho; Maruo, Kazushi; Takebayashi, Yoshitake; Shinmei, Issei; Yoshimoto, Shigeka; Horikoshi, Masaru

doi:10.1186/s12888-018-1795-7

Cited by 19 publications

(21 citation statements)

References 41 publications

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“…Thirteen articles described new tests that took advantage of the mobile platform. Five discussed short tests for mass screening (Brouillette et al, 2013; Onoda et al, 2013; Onoda & Yamaguchi, 2014; Possin et al, 2018; Scanlon et al, 2016), five discussed test batteries covering several domains of cognitive function (Freedman et al, 2018; Kokubo et al, 2018; Makizako et al, 2013; Rentz et al, 2016; Zorluoglu et al, 2015), and three described tests designed for repeated administration (Allard et al, 2014; Jongstra et al, 2017; Lange & Suss, 2014). Screening tests require a relatively short time to complete and focus on general cognitive function or a few specific domains known to change in the early stages of cognitive decline.…”

Section: Resultsmentioning

confidence: 99%

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Mobile Technology for Cognitive Assessment of Older Adults: A Scoping Review

Koo

Vizer

2019

Innovation in Aging

158

125

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Background and ObjectivesThe number of people diagnosed with dementia is rising appreciably as the population ages. In an effort to improve outcomes, many have called for facilitating early detection of cognitive decline. Increased use of mobile technology by older adults provides the opportunity to deliver convenient, cost-effective assessments for earlier detection of cognitive impairment. This article presents a review of the literature on how mobile platforms—smartphones and tablets—are being used for cognitive assessment of older adults along with benefits and opportunities associated with using mobile platforms for cognitive assessment.Research Design and MethodsWe searched MEDLINE, Web of Science, PsycInfo, CINAHL, EMBASE, and Cochrane Central Register of Controlled Trials in October 2018. This search returned 7,024 articles. After removing 1,464 duplicates, we screened titles and abstracts then screened full-text for those articles meeting inclusion and exclusion criteria.ResultsTwenty-nine articles met our inclusion criteria and were categorized into 3 groups as follows: (a) mobile versions of existing article or computerized neuropsychological tests; (b) new cognitive tests developed specifically for mobile platforms; and (c) the use of new types of data for cognitive assessment. This scoping review confirms the considerable potential of mobile assessment.Discussion and ImplicationsMobile technologies facilitate repeated and continuous assessment and support unobtrusive collection of auxiliary behavioral markers of cognitive impairment, thus allowing users to view trends and detect acute changes that have traditionally been difficult to identify. Opportunities include using new mobile sensors and wearable devices, improving reliability and validity of mobile assessments, determining appropriate clinical use of mobile assessment information, and incorporating person-centered assessment principles and digital phenotyping.

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Section: Resultsmentioning

confidence: 99%

“…The User eXperience-Trail Making Test (UX-TMT) was developed for cognitive assessment and training (Kokubo et al, 2018). The UX-TMT consists of neurocognitive assessment, cognitive training, and life-logging.…”

Section: Resultsmentioning

confidence: 99%

Mobile Technology for Cognitive Assessment of Older Adults: A Scoping Review

Koo

Vizer

2019

Innovation in Aging

158

125

View full text Add to dashboard Cite

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“…In the Trails Test, PD patients also needed more time and committed more errors than controls. Although several previous studies reported deficits on the TMT in PD ( Muslimoviæ et al, 2005 ; Colman et al, 2009 ; Godefroy et al, 2010 ; Dirnberger and Jahanshahi, 2013 ; Kourtidou et al, 2015 ; Hessen et al, 2016 ; Vlagsma et al, 2017 ; Hoogland et al, 2018 ), other studies reported no difference between PD and controls ( Bouquet et al, 2003 ; Kokubo et al, 2018 ), even in PD patients with ICD ( MacK et al, 2013 ). Cools et al (2001) have argued that impairment in task-set switching only appears when competing information is present, i.e., when the load on selection mechanisms increases.…”

Section: Discussionmentioning

confidence: 85%

Cognitive and Behavioral Inhibition Deficits in Parkinson’s Disease: The Hayling Test as a Reliable Marker

Siquier

Andrés

2021

Front. Aging Neurosci.

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ObjectiveThe present study seeks to provide an overview of executive (inhibition and flexibility) deficits in Parkinson’s disease (PD) by combining a cognitive and behavioral approach.MethodsFifteen PD patients and 15 healthy controls underwent a neuropsychological and behavioral assessment including the Hayling and Trails Tests, the Questionnaire for Impulsive–Compulsive Disorders in Parkinson’s Disease (QUIP-RS), the Behavior Rating Inventory of Executive Function (BRIEF-A), and the Short Form-36 Health Survey (SF-36). The level of awareness of executive functioning was also analyzed. We finally explored how these neuropsychological and clinical outcomes could relate to each other.ResultsPD patients performed significantly worse in both neuropsychological tasks designed to evaluate inhibition abilities. They also reported more inhibition difficulties in everyday life and poorer quality of life. Associations between neuropsychological measures and self-reports were found. Moreover, as indicated by the discrepancy score, PD patients were as accurate as their relatives in self-reporting their executive daily difficulties.ConclusionInhibition and cognitive flexibility impairments assessed by the neuropsychological tests (Hayling and Trails tests) seem to capture daily life executive problems in PD. Furthermore, our study provides a deeper understanding of PD patients’ and their relatives’ experience of these executive dysfunctions.

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“…Besides digital CDT, some other digital drawing tests have been suggested in the literature. The digital pentagon drawing test (Garre-Olmo et al, 2017;Tsoi et al, 2018) and digital ROCF (Cheah et al, 2019;Kokubo et al, 2018) are adapted from paper-and-pencil versions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Digital Drawing Tests and Paper-and-Pencil Drawing Tests for the Screening of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies

et al. 2021

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Digital drawing tests have been proposed for cognitive screening over the past decade. However, the diagnostic performance is still to clarify. The objective of this study was to evaluate the diagnostic performance among different types of digital and paper-and-pencil drawing tests in the screening of mild cognitive impairment (MCI) and dementia. Diagnostic studies evaluating digital or paper-and-pencil drawing tests for the screening of MCI or dementia were identified from OVID databases, included Embase, MEDLINE, CINAHL, and PsycINFO. Studies evaluated any type of drawing tests for the screening of MCI or dementia and compared with healthy controls. This study was performed according to PRISMA and the guidelines proposed by the Cochrane Diagnostic Test Accuracy Working Group. A bivariate random-effects model was used to compare the diagnostic performance of these drawing tests and presented with a summary receiver-operating characteristic curve. The primary outcome was the diagnostic performance of clock drawing test (CDT). Other types of drawing tests were the secondary outcomes. A total of 90 studies with 22,567 participants were included. In the screening of MCI, the pooled sensitivity and specificity of the digital CDT was 0.86 (95% CI = 0.75 to 0.92) and 0.92 (95% CI = 0.69 to 0.98), respectively. For the paper-and-pencil CDT, the pooled sensitivity and specificity of brief scoring method was 0.63 (95% CI = 0.49 to 0.75) and 0.77 (95% CI = 0.68 to 0.84), and detailed scoring method was 0.63 (95% CI = 0.56 to 0.71) and 0.72 (95% CI = 0.65 to 0.78). In the screening of dementia, the pooled sensitivity and specificity of the digital CDT was 0.83 (95% CI = 0.72 to 0.90) and 0.87 (95% CI = 0.79 to 0.92). The performances of the digital and paper-and-pencil pentagon drawing tests were comparable in the screening of dementia. The digital CDT demonstrated better diagnostic performance than paper-and-pencil CDT for MCI. Other types of digital drawing tests showed comparable performance with paper-and-pencil formats. Therefore, digital drawing tests can be used as an alternative tool for the screening of MCI and dementia.

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A new device-aided cognitive function test, User eXperience-Trail Making Test (UX-TMT), sensitively detects neuropsychological performance in patients with dementia and Parkinson’s disease

Cited by 19 publications

References 41 publications

Mobile Technology for Cognitive Assessment of Older Adults: A Scoping Review

Mobile Technology for Cognitive Assessment of Older Adults: A Scoping Review

Cognitive and Behavioral Inhibition Deficits in Parkinson’s Disease: The Hayling Test as a Reliable Marker

Evaluation of Digital Drawing Tests and Paper-and-Pencil Drawing Tests for the Screening of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies

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