Depression and anxiety disorders among patients with human T-cell lymphotropic virus type-1: a cross-sectional study with a comparison group

Rocha-Filho, Pedro Augusto Sampaio; Goncalves, Liliana Raulino

doi:10.1590/0037-8682-0365-2016

Cited by 12 publications

(10 citation statements)

References 12 publications

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“…Our findings showing no associations between HTLV-1 and cognitive function differ from several other previous reports that have shown associations between HTLV-1 and cognitive function and depression in comparisons of HAM/TSP with healthy controls and with asymptomatic HTLV-1 and healthy controls [10,11,19,21]. Several factors could plausibly account for the differences between our findings and previous reports that found associations between HTLV-1 and cognitive function and between HTLV-1 and depression.…”

Section: Discussioncontrasting

confidence: 98%

“…In addition to its association with worse cognitive function, HTLV-1 also has been associated with depression and anxiety. A cross-sectional study from Brazil that investigated 20 patients with HAM/TSP, 38 asymptomatic HTLV-1 patients, and 340 healthy controls found that both HAM/TSP and asymptomatic HTLV-1 were associated with depression and anxiety [11], although the analyses in this study were not adjusted for covariates that could potentially influence the association between HTLV-1 and either depression or anxiety. Another study from Brazil compared levels of depression and anxiety between 63 patients with HAM/TSP and 67 patients with asymptomatic HTLV-1, finding that the patients with HAM/TSP had more depression and anxiety than the asymptomatic HTLV-1 group.…”

Section: Introductionmentioning

confidence: 74%

“…Several viral, bacterial, and parasitic diseases appear to be associated with cognitive function and dementia [1][2][3][4][5][6] and with neuropsychiatric disease in humans [7][8][9]. Among the infectious diseases associated with cognitive function and with neuropsychiatric outcomes in humans is human T-cell lymphotropic virus 1 (HTLV-1) [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults

et al. 2021

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Several viral, bacterial, and parasitic diseases have been associated with cognitive function and neuropsychiatric outcomes in humans, including human T-cell lymphotropic virus 1 (HTLV-1). In this study, we sought to further generalize previously reported associations of cognitive function and depression with HTLV-1 seropositivity and serointensity using a community-based sample of adults aged approximately 40 to 70 years (mean = 55.3 years) from the United Kingdom. In this sample, the results of adjusted linear regression models showed no associations of HTLV-1 seropositivity or serointensity with reasoning, pairs-matching, or reaction-time cognitive tasks or with depression. In addition, neither age, sex, educational attainment, nor income moderated associations of HTLV-1 seropositivity or serointensity with cognitive function or depression. In this middle-aged to older middle-aged adult community sample, HTLV-1 seropositivity and serointensity do not appear to be associated with reasoning, pairs-matching, and reaction-time tasks or with depression.

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Section: Discussioncontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults

et al. 2021

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“…However, studies have shown that HTLV-1 seropositive individuals may present with a broad range of clinical manifestations, including inflammatory syndromes (uveitis, thyroiditis, and alveolitis), neurological symptoms not explained by myelopathy (polyneuropathy, myositis, dysautonomia), and opportunistic co-infections (strongyloidiasis, tuberculosis, and aspergillosis) 7 . Some studies have even shown that HTLV-1 infection may be associated with clinical depression and nutritional deficiencies 16,17 . However, the vast majority of patients that are HTLV-1 positive remain asymptomatic, and the precise mechanisms underlying the development of symptoms in a subgroup of patients remain to be determined 14 .…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of human T-lymphotropic virus type I: a forgotten infection in pediatrics

Mejía-Mertel

Gómez-Banoy

Hernández

et al. 2020

Infect

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The Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus with oncogenic properties, affects around ten to twenty million people worldwide. The most common disorders associated with HTLV-1 infection are T-cell leukemia/lymphoma (ALT) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Studies have reported other clinical manifestations in HTLV-1 seropositive patients, including inflammatory disorders, co-infections with opportunistic agents, and pulmonary diseases. Objective: Here, we aim to describe a cohort of juvenile patients with confirmed HTLV-1 infection that showed clinical manifestations other than neurological symptoms. Methodology and patients: Retrospective analysis of clinical data describing background and clinical findings of 12 juvenile patients with confirmed HTLV-1 infection, attended during January 2018 to February 2020 in a pediatric referral hospital in Cali, Colombia. Results: 11 out 12 patients were from Colombia´s Pacific coast, 10 suffered from significant nutritional deficiencies. Six exhibited dermatological findings, 3 compatible with infective dermatitis. None of the cases exhibited clinical or laboratory findings suggesting ALT or HAM/TPS. Eight patients had structural lung disease assessed by chest Computed Tomography (CT) scans; 4 of them tested positive for galactomannan antigen in bronchoalveolar fluid suggesting pulmonary aspergillosis, and 2 others exhibited a positive PCR testing for tuberculosis. Three patients were diagnosed with autoimmune disorders; 1 patient with Crohn´s Diseases, 1 case of autoimmune thrombocytopenic purpura, and a patient with Vogt-Koyanagi-Harada syndrome (non-granulomatous uveitis). Conclusions: There is a broad range of clinical manifestations in pediatric HTLV-1 patients, and the clinician should consider structural pulmonary disease, opportunistic co-infections and autoimmune disorders in the diagnostic algorithm.

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“…Screening for depression during pregnancy may be useful in evaluating both aspects [100]. Rocha-Filho et al showed that both symptomatic and asymptomatic patients with HTLV-1 experienced more anxiety and depression than those experienced by uninfected patients [101]. Thus, it is believed that carrier mothers may have similar experiences.…”

Section: Prevention Of Mtct By Nutritional Regimensmentioning

confidence: 99%

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

Itabashi

Miyazawa

2021

Cancers

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Approximately 95% of mother-to-child transmission (MTCT) of human T-cell leukemia virus type-1 (HTLV-1) is derived from prolonged breastfeeding, which is a major cause of adult T-cell leukemia (ATL). Exclusive formula feeding (ExFF) is therefore generally used to prevent MTCT. A recent cohort study revealed that 55% of pregnant carriers chose short-term breastfeeding for ≤ 3 months in Japan. Our meta-analysis showed that there was no significant increase in the risk of MTCT when breastfeeding was carried out for ≤ 3 months compared with ExFF (pooled relative risk (RR), 0.72; 95% confidence interval (CI), 0.30–1.77), but there was an almost threefold increase in risk when breastfeeding was carried out for up to 6 months (pooled RR, 2.91; 95% CI, 1.69–5.03). Thus, short-term breastfeeding for ≤ 3 months may be useful in preventing MTCT. Breastmilk is the best nutritional source for infants, and any approach to minimizing MTCT by avoiding or limiting breastfeeding must be balanced against the impact on the child’s health and mother–child bonding. To minimize the need for nutritional interventions, it is necessary to identify factors that predispose children born to carrier mothers to MTCT and thereby predict MTCT development with a high degree of accuracy.

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Depression and anxiety disorders among patients with human T-cell lymphotropic virus type-1: a cross-sectional study with a comparison group

Abstract: Symptomatic and asymptomatic patients with HTLV-1 experienced more anxiety and depression than uninfected patients.

Cited by 12 publications

References 12 publications

Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults

Association between Cognitive Function and Depression with Human T-Cell Lymphotropic Virus 1 Seropositivity and Serointensity in UK Adults

Clinical profile of human T-lymphotropic virus type I: a forgotten infection in pediatrics

Mother-to-Child Transmission of Human T-Cell Leukemia Virus Type 1: Mechanisms and Nutritional Strategies for Prevention

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