Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients

Abstract

Early diagnosis and treatment of VIAU in immunocompromised patients can be achieved with high suspicion, recognizing clinical features, and obtaining specimens for molecular diagnostic testing in order to avoid usually severe ocular morbidity.

Varicella Zoster Virus Anterior Uveitis Complicated by Thalamic Stroke

“…Anterior uveitis can be associated with infectious or noninfectious etiologies, and timely diagnosis is essential to guide appropriate treatment and minimize the potential for systemic morbidity, particularly in cases where non-ophthalmic ndings develop [3,4]. Our patient was undergoing workup for in ammatory bowel disease and arthritis and was treated initially with oral corticosteroids, which may have contributed her protracted disease course.…”

“…Interestingly, our patient did not show typical cutaneous manifestations and presented at a younger age than most individuals, as VZV anterior uveitis is more commonly observed in elderly patients. Even in the absence of a history of herpetic zoster ophthalmicus, clinical suspicion for a viral process should remain high in patients with characteristic ophthalmic ndings including hypertensive anterior uveitis, particularly in conjunction with sectoral iris atrophy [3]. PCR of aqueous humor is a highly sensitive test to con rm the diagnosis following aspiration of intraocular uid, which can be performed in the ophthalmic clinic setting [8].…”

Varicella zoster virus anterior uveitis complicated by thalamic stroke

“…Anterior uveitis can be associated with infectious or noninfectious etiologies, and timely diagnosis is essential to guide appropriate treatment and minimize the potential for systemic morbidity, particularly in cases where non-ophthalmic findings develop [1,2]. Our patient was undergoing workup for inflammatory bowel disease and arthritis and was treated initially with oral corticosteroids, which may have contributed her protracted disease course.…”

Varicella Zoster Virus Anterior Uveitis Complicated by Thalamic Stroke

“…Anterior uveitis can be associated with infectious or noninfectious etiologies, and timely diagnosis is essential to guide appropriate treatment and minimize the potential for systemic morbidity, particularly in cases where non-ophthalmic ndings develop [3,4]. Our patient was undergoing workup for in ammatory bowel disease and arthritis and was treated initially with oral corticosteroids, which may have complicated her disease course.…”

“…Interestingly, our patient did not show typical cutaneous manifestations and presented at a younger age than most individuals, as VZV anterior uveitis is more commonly observed in elderly patients. Even in the absence of a history of herpetic zoster ophthalmicus, clinical suspicion for a viral process should remain high in patients with characteristic ophthalmic ndings [3]. PCR of aqueous humor is a highly sensitive test to con rm the diagnosis following aspiration of intraocular uid, which can be performed in the ophthalmic clinic setting [8].…”