A paper platform for colorimetric determination of aluminum hydrochloride in antiperspirant samples

Silvestre, Amanda Letícia Polli; Milani, Maria Izabel; Rossini, Eduardo Luiz; Pezza, Leonardo; Pezza, Helena Redigolo

doi:10.1016/j.saa.2018.06.049

Cited by 8 publications

(4 citation statements)

References 28 publications

(28 reference statements)

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“…Aluminum hydrochloride is a potential neurotoxic agent in cosmetic antiperspirants [189] which is associated with the risk of cognitive disorders such as neurodegenerative diseases. Moreover, aluminum exposure in rats was shown to cause spatial learning damage and impairs memory functions, mediated by increased expression of histone deacetylase 6 (HDAC6), reduced H3K9, and H4K12 acetylation at the promoter of the brainderived neurotrophic factor (BDNF), which will eventually inhibit BDNF expression [190].…”

Section: Aluminum Hydrochloridementioning

confidence: 99%

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

et al. 2022

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Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes.

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Section: Aluminum Hydrochloridementioning

confidence: 99%

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

et al. 2022

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“…The spectrometric determination of aluminum in antiperspirants has been described using several methods as UV‐Vis spectrophotometry, [7–9] molecular fluorescence spectrometry, [10–12] atomic absorption spectrometry, [13] inductively coupled plasma optical emission spectrometry, [14,15] and others. Most of them require complex chemical derivatization, time‐consuming sample preparation steps, or rely on expensive analytical instrumentation, which can be a limiting factor for some applications.…”

Section: Introductionmentioning

confidence: 99%

“…[6] In spite of the occurrence of high Al levels in breast tissues and human exposure to this metal on daily basis, several studies associating aluminum with health damage have been addressed over the last decades, but most findings were inconclusive or lacked evidence. [5] The spectrometric determination of aluminum in antiperspirants has been described using several methods as UV-Vis spectrophotometry, [7][8][9] molecular fluorescence spectrometry, [10][11][12] atomic absorption spectrometry, [13] inductively coupled plasma optical emission spectrometry, [14,15] and others. Most of them require complex chemical derivatization, time-consuming sample preparation steps, or rely on expensive analytical instrumentation, which can be a limiting factor for some applications.…”

Section: Introductionmentioning

confidence: 99%

Direct Determination of the Aluminum Content in Antiperspirants Using Digital Image Colorimetry

Teixeira,

Virgilio,

Santos

2023

ChemistrySelect

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In this work a dilute‐and‐shoot procedure using digital image colorimetry (DIC) was evaluated for the determination of aluminum in antiperspirants. Derivatization was performed by means of the reaction between Al(III) and Alizarin Red S (ARS) reagent. Digital images were acquired using a table scanner and the average values for red, green and blue channels (RGB) were obtained. Optimal conditions were set at pH=4.5, ARS concentrations 10‐fold higher than Al(III) and using the G channel. The method presented linearity in the 2.0–10.0 mg L−1 range, the limit of detection (LOD) was 1.1 mg L−1 and precision was better than 2.55 %. Accuracy was checked by the analysis of spiked samples at 2.0 and 4.0 mg L−1 Al(III), and good recoveries (82.6–117.5 %) were obtained. Eight samples of roll‐on antiperspirants were analyzed by the proposed colorimetric method and the well‐stablished flame atomic absorption spectrometry (FAAS) comparative method. The obtained results were not statistically different at 95 % confidence level. An analytical greenness assessment was performed for both methods and the procedure based on digital image colorimetry was proven to be a greener approach due to miniaturization, low sample consumption, least amount of waste and high sample throughput.

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“…These methodologies usually employ organic solvents that generate toxic residues, thus, offering risks to the environment and to the operator. In addition, they depend on specific instrumentation, which is not often available (Silvestre et al, 2018). Based on these considerations, this study was conducted with a modified methodology described by Gasparini et al (2008) making it even simpler, faster, environmentally friendly, using low volume of reagents and sample (Gasparini et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative analysis of formaldehyde in samples of hair straighteners and suitability of the labels

Silvestre

Fagá

Almeida-Cincotto

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

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Formaldehyde is an active compound, irregularly used in hair products, that has the property of straighten and waterproofing the wires. However, it is highly toxic and can stimulate dermatological hypersensitivity and cancer. In this context it is of fundamental importance the inspection of these products that can be used in safe conditions for the consumer, without formaldehyde in concentrations higher than the allowed. Thus, the aim of this research was the qualitative and quantitative identification formaldehyde in samples of hair straighteners that was obtained by donation in the beauty salons of Araraquara-SP. In addition, the analysis of the packaging labels of the products tested were conducted, following the requirements of the national legislation-RDC 07/2015 which defines the mandatory labeling standards for cosmetic products. A qualitative analysis for formaldehyde identification is based on the formation of a purple colored complex. The quantitative analysis was performed by spectrophotometry. The qualitative and quantitative formaldehyde analysis methods were applied to 13 bottles of hair straighteners. When submitted to qualitative analysis, all samples showed formaldehyde presence. The quantitative analysis demonstrated that the samples identified as B, C, D, E, G, H, I, J and M presented formaldehyde concentration of 3.5 to 14.5%, which is above of the limit recommended by the National Health Surveillance Agency (ANVISA), of 0.2%. In the label analysis, in all samples were found irregularities.

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A paper platform for colorimetric determination of aluminum hydrochloride in antiperspirant samples

Cited by 8 publications

References 28 publications

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Direct Determination of the Aluminum Content in Antiperspirants Using Digital Image Colorimetry

Qualitative and quantitative analysis of formaldehyde in samples of hair straighteners and suitability of the labels

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