Non-neoplastic adrenal pseudocysts: A clinicopathologic study of 44 cases with potential insights into pathogenesis

Koperski, Łukasz; Pihowicz, Paweł; Fus, Łukasz; Bogdańska, Magdalena; Górnicka, Barbara

doi:10.1016/j.anndiagpath.2018.06.006

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…4 Histologically, the cysts often demonstrate an attenuated endothelial lining, highlighted by CD31, CD34, and ERG. 1,4,[10][11][12] The pathogenesis of vascular cysts is unclear and has been suggested to arise either from a preexisting vascular hamartoma or ectasia of lymphatic channels or secondary to intraparenchymal hemorrhage. 2,4,10,13 Vascular cysts have been noted to contain some component of PEH, but rarely is it the primary finding.…”

Section: Discussionmentioning

confidence: 99%

“…Grossly, vascular cysts are encapsulated and may contain blood or amorphous material 4 . Histologically, the cysts often demonstrate an attenuated endothelial lining, highlighted by CD31, CD34, and ERG 1,4,10–12 . The pathogenesis of vascular cysts is unclear and has been suggested to arise either from a preexisting vascular hamartoma or ectasia of lymphatic channels or secondary to intraparenchymal hemorrhage 2,4,10,13 .…”

Section: Discussionmentioning

confidence: 99%

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Papillary Endothelial Hyperplasia of the Adrenal Gland: A Case Report and Review of the Literature

Limbach¹,

Wakely²

2022

AJSP: Reviews and Reports

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Adrenal cysts are becoming more commonly identified because of advances in imaging techniques. The differential diagnosis of adrenal cysts is broad, and an uncommon finding in the cyst is papillary endothelial hyperplasia (PEH). Papillary endothelial hyperplasia is a benign endothelial proliferation which is most commonly described in the skin, and is uncommonly seen in visceral organs. We report a case of a 36 year old woman who presented with abdominal pain and subsequent imaging revealed an adrenal cyst. The patient then underwent surgery with removal of a 3.6 cm cystic adrenal gland. Histologic examination revealed numerous papillary structures covered by benign endothelial cells (CD34, CD31, ERG positive) consistent with PEH. Given the rarity of PEH as the predominant finding in the adrenal gland, recognition of PEH as a benign entity is important. In this report we present our case in the context of the literature and review differential diagnosis of PEH in the adrenal gland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Papillary Endothelial Hyperplasia of the Adrenal Gland: A Case Report and Review of the Literature

Limbach¹,

Wakely²

2022

AJSP: Reviews and Reports

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“…A fluid attenuation (>30 HU) may indicate hemorrhage, intracystic debris, or calcifications which are present in 15 to 70% of cases. 3 15 Because of the difficulty in coming to a definitive preoperative diagnosis due to its varied radiological presentations a cyst aspiration after ruling out pheochromocytoma or surgical excision is often needed to rule out malignancy. The risk of malignancy is high with cystic adrenal lesions that are heterogeneous, larger than 5 cm in size, thick-walled, or symptomatic.…”

Section: Discussionmentioning

confidence: 99%

Giant Adrenal Pseudocysts: An Enigma for Surgeons

Parasar

Mohan

John³

et al. 2022

Surg J (N Y)

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Adrenal pseudocysts are cystic lesions arising within the adrenal gland enclosed by a fibrous connective tissue wall that lacks lining cells. They can attain a huge size and pose a diagnostic challenge with a broad range of differentials including benign and malignant neoplasms. There are only a few small case series and case reports describing these lesions. We report a series of five patients who presented with “indeterminate” abdominal cystic lesions and were later on found to have adrenal pseudocyst. Four out of five patients presented with non-specific abdominal symptoms, and one patient presented with symptoms suggestive of a functional adrenal tumor. The size of these tumors ranged from 6 to 30 cm. They had variable radiological features and in two cases even a percutaneous biopsy could not establish the diagnosis. In four of these “indeterminate” abdominal masses, an adrenal origin was not suspected preoperatively. Surgical excision provided a resolution of symptoms, ruled out malignancy, and clinched the diagnosis.

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Cystic lymphangiomatous lesions of the adrenal gland: A clinicopathological study of 37 cases including previously unreported cysts with papillary endothelial proliferation

Koperski

Pihowicz

Anysz-Grodzicka

et al. 2019

Pathology - Research and Practice

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Non-neoplastic adrenal pseudocysts: A clinicopathologic study of 44 cases with potential insights into pathogenesis

Cited by 3 publications

References 13 publications

Papillary Endothelial Hyperplasia of the Adrenal Gland: A Case Report and Review of the Literature

Papillary Endothelial Hyperplasia of the Adrenal Gland: A Case Report and Review of the Literature

Giant Adrenal Pseudocysts: An Enigma for Surgeons

Cystic lymphangiomatous lesions of the adrenal gland: A clinicopathological study of 37 cases including previously unreported cysts with papillary endothelial proliferation

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