Peripheral Lymphocytes, Obesity, and Metabolic Syndrome in Young Adults: An Immunometabolism Study

Rodríguez, Carmen Paulina; González, Marı́a Cristina; Aguilar-Salinas, Carlos A.; Nájera-Medina, Oralia

doi:10.1089/met.2018.0005

Cited by 26 publications

(32 citation statements)

References 39 publications

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“…Obesity is a chronic public health problem that affects millions of individuals throughout the world. It is recognized as a heterogeneous condition, as individuals with a similar body mass index (BMI) may have different metabolic and cardiovascular risks [1]. It is a chronic debilitating disease that is particularly serious in the USA, where it affects ~40% of the population [1, 2].…”

Section: Introductionmentioning

confidence: 99%

“…It is recognized as a heterogeneous condition, as individuals with a similar body mass index (BMI) may have different metabolic and cardiovascular risks [1]. It is a chronic debilitating disease that is particularly serious in the USA, where it affects ~40% of the population [1, 2]. Obesity has a strong causal relationship with a number of comorbidities, leading to a loss of quality of life, a lower life expectancy and socioeconomic costs.…”

Section: Introductionmentioning

confidence: 99%

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Bariatric surgery and the evaluation of subclinical systemic lymphedema

Godoy

Godoy³

et al. 2019

Journal of Surgical Case Reports

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The aim of the study was to report an improvement in clinical lymphedema in a patient who went from morbid obesity to overweight following bariatric surgery. A 52-year-old female patient reported having undergone bariatric surgery with a body mass index (BMI) of 51.2 kg/m2, losing 40 kg and arriving at her current BMI of 37.1 kg/m2. She would previously awake with bilateral edema that involved her feet and worsened throughout the day, corresponding to clinical stage II lymphedema, and currently no longer had this problem. Eight years after the surgery and weight loss, the patient was submitted to electrical bioimpedance analysis, which revealed an increase in total intracellular and extracellular fluids in the limbs and trunk. Active exercise and further weight loss were recommended. This study paves a path for a new line of investigation in the treatment of obesity and changes in the lymphatic system caused by obesity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bariatric surgery and the evaluation of subclinical systemic lymphedema

Godoy

Godoy³

et al. 2019

Journal of Surgical Case Reports

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“…Adipose tissue also directly influences the function of the immune system through production of pro‐inflammatory cytokines 18,19 . Of note, changes in frequencies of circulating lymphocytes, monocytes and natural killer cells have been described in both obesity 20‐22 and MDD 23‐26 …”

Section: Introductionmentioning

confidence: 99%

Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study

Stiglbauer

Gamradt

Scherzer

et al. 2021

Cell Biochemistry & Function

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In this pilot study, we explored the immune phenotype of patients with severe obesity and comorbid depressive symptoms compared to non‐depressed patients with obesity and normal‐weight controls. Immune cell subsets were analysed by flow cytometry and depressive symptoms assessed using the Patient Health Questionnaire (PHQ‐9). Cell frequencies were correlated with depressive symptom scores and waist‐to‐hip ratio (WHR). Patients with obesity and comorbid depression showed significantly lower numbers of circulating cytotoxic natural killer cells, dendritic cells and CD8+ effector memory T cells, compared to normal‐weight controls. Regulatory T cells and CD4+ central memory T cells were increased compared to non‐depressed patients with obesity and compared to normal‐weight controls, respectively. Frequencies of cytotoxic natural killer cells and CD4+ central memory T cells significantly correlated with PHQ‐9 scores, but not with WHR. Reduced numbers of dendritic cells were observed in both patient groups with obesity and correlated with PHQ‐9 scores and WHR. These findings provide evidence for an altered immune composition in comorbid obesity and depression, supporting a pathobiological overlap between the two disorders.

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“…Weight loss is a challenge for these patients, many of whom seek solutions, such as bariatric surgery, but the metabolic problem often persists. 1 Obesity has been associated with lower limb lymphedema, which is yet another aggravating factor for this patients. 2 Lymphedema is a clinical condition that leads to the buildup of macromolecules in the interstitial space, which, in turn, leads to the accumulation of liquids.…”

Section: Introductionmentioning

confidence: 99%

The Course of Subclinical Systemic Lymphedema Over a Six-Year Period

Godoy¹,

Godoy²,

Melo³

et al. 2020

JBINO

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The aim of the present study was to evaluate the course of subclinical systemic lymphedema over a six-year period using bioelectrical impedance analysis. A 44-year-old woman sought our clinic six years ago with the complaint of pain and swelling in the legs upon waking that aggravated throughout the course of the day. The physical exam revealed edema in the legs and obesity, with a body mass index (BMI) of 50.6 kg/m 2. Bioelectrical impedance analysis was performed and revealed an increase in total intracellular and extracellular water beyond the range of normality. Over a six-year period, the patient lost 12 kilograms and her BMI was lowered, but the pattern of intracellular and extracellular water remained the same. Obesity is associated with an increase in body water characterizing subclinical systemic lymphedema, which is maintained over the years. A reduction in weight may lead to a reduction in the volume of liquids.

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Peripheral Lymphocytes, Obesity, and Metabolic Syndrome in Young Adults: An Immunometabolism Study

Abstract: Significant changes were detected in the subpopulations of lymphocytes, suggesting that weight gain, SMM, and VAT accumulation gave rise to immunological changes at the peripheral level, and the presence of increased memory cells could be related to low-intensity chronic inflammation.

Cited by 26 publications

References 39 publications

Bariatric surgery and the evaluation of subclinical systemic lymphedema

Bariatric surgery and the evaluation of subclinical systemic lymphedema

Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study

The Course of Subclinical Systemic Lymphedema Over a Six-Year Period

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