2018
DOI: 10.1038/s41380-018-0116-3
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Treatment strategies for ADHD: an evidence-based guide to select optimal treatment

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Cited by 203 publications
(188 citation statements)
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References 197 publications
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“…Also, our findings are only partially consistent with recommendations from available guidelines or expert consensus papers. Indeed, our results are in line with:1) the guidelines from the National Institute of Clinical Care and Excellence ( 25 ) on the use of fluoxetine for moderate to severe depression; 2) the lack of endorsement for antidepressants to treat ADHD ( 26 ), PTSD ( 27 ), or core symptoms of ASD ( 28 ). However, our findings are at odds with: 1) expert guidance suggesting the use of imipramine for pediatric enuresis ( 29 ); 2) the recommendation to use fluoxetine, rather than fluvoxamine, among the SSRIs, for ADs ( 30 ); 3) the NICE guidelines recommending the use of imipramine, albeit only when enuresis has proved resistant to all other treatment options ( 31 ).…”
Section: Discussionsupporting
confidence: 86%
“…Also, our findings are only partially consistent with recommendations from available guidelines or expert consensus papers. Indeed, our results are in line with:1) the guidelines from the National Institute of Clinical Care and Excellence ( 25 ) on the use of fluoxetine for moderate to severe depression; 2) the lack of endorsement for antidepressants to treat ADHD ( 26 ), PTSD ( 27 ), or core symptoms of ASD ( 28 ). However, our findings are at odds with: 1) expert guidance suggesting the use of imipramine for pediatric enuresis ( 29 ); 2) the recommendation to use fluoxetine, rather than fluvoxamine, among the SSRIs, for ADs ( 30 ); 3) the NICE guidelines recommending the use of imipramine, albeit only when enuresis has proved resistant to all other treatment options ( 31 ).…”
Section: Discussionsupporting
confidence: 86%
“…18 Availability of treatment may also be related to increases in the diagnosis of ADHD, as there are many effective pharmacologic and nonpharmacologic treatments that have been and continue to be developed to address ADHD symptoms and associated negative functioning. 19…”
Section: Adhdmentioning
confidence: 99%
“…Most of the action of synaptic dopamine is terminated via uptake of dopamine by the dopamine uptake transporter (DAT). The dopamine uptake transporter is one of the primary targets for medications that are used to treat ADHD (101, 102). Thus, dopamine neurotransmission plays a role in both impulsivity and psychostimulant addiction.…”
Section: Pharmacological Targets To Treat Psychostimulant-induced Cogmentioning
confidence: 99%
“…The role of noradrenaline in impulsivity is evident by use of medications that increase noradrenergic transmission in the treatment of ADHD (101, 102). Noradrenergic transmission is mediated by α (α1 and α2) and β (β1 and β2) adrenergic receptors, and the action of synaptic noradrenaline is terminated by the noradrenaline uptake transporter (NET).…”
Section: Pharmacological Targets To Treat Psychostimulant-induced Cogmentioning
confidence: 99%